77355-00-1

Upstream product

• 110-52-1 1,4-dibromo-butane 
• 123-08-0 4-hydroxy-benzaldehyde 
• 623-05-2 (4-hydroxyphenyl)methanol 
• 58765-11-0 4-hydroxybenzaldehyde potassium salt 
• 110-56-5 1,4-dichlorobutane 
• 628-21-7 1,4-Diiodobutane 

Downstream Products

• 3749-77-7 4,4'-butanediyldioxy-di-benzoic acid 
• 112867-43-3 4,4'-butanediyldioxy-di-benzaldehyde bis-carbamimidoylhydrazone 
• 16834-63-2 3-(4-{4-[4-(2,2-Bis-ethoxycarbonyl-vinyl)-phenoxy]-butoxy}-phenyl)-2-ethoxycarbonyl-acrylic acid ethyl ester 
• 252006-62-5 (2E,2E)-3,3-(4,4-(butane-1,4-diylbis(oxy))bis(4,1-phenylene))bis(1-phenylprop-2-en-1-one) 
• 872132-68-8 N'-[1-(4-{4-[4-(Methylsulfanylthiocarbonyl-hydrazonomethyl)-phenoxy]-butoxy}-phenyl)-meth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester 

Relevant academic research and scientific papers

Bi-nuclear luminescent europium(III) molecular complexes for white light emitting diodes: Experimental and theoretical study

Two newly designed and synthesized ancillary ligands with N1 functionalization (phenyl and fluorene) and its influence on photophysical properties of their corresponding binuclear europium complexes were investigated systematically. Photoluminescence (PL)

An investigation of physico-chemical properties of a new polyimide-silica composites

In the present study, a novel diamine 1,4-bis[4-(hydrazonomethyl)phenoxy]butane (4-BHPB) has been successfully synthesized by a facile method. 4-BHPB was reacted with pyromellitic dianhydride (PMDA) to derive a novel polyimide (PI). Highly compatibilized

Synthesis and characterization of new heat resistance and organosoluble poly(ether-amide)

New series of olefinic poly(ether-amide)s (OPEA)s 6a-f was synthesized from 4,4′-bis(1,4- diphenoxybutane)diacrylic acid 4 and aromatic diamine 5a-f via a direct polycondensation reaction. The resulting polymers were characterized by Fourier transform inf

Terpyridine-based metallo-organic cages and supramolecular gelation by coordination-driven self-assembly and host-guest interaction

Host-guest complexation based on terpyridine (tpy) three-dimensional (3D) metallo-cages has received less attention due to the complicated structure and solubility issues. Herein, a three-armed metallo-organic ligand (L) was synthesized via three 120°-ben

Introduction of a trinuclear manganese(iii) catalyst on the surface of magnetic cellulose as an eco-benign, efficient and reusable novel heterogeneous catalyst for the multi-component synthesis of new derivatives of xanthene

In this work, the new trinuclear manganese catalyst defined as Fe3O4@NFC@NNSM-Mn(iii) was successfully manufactured and fully characterized by different techniques, including FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP analysis. There have been reports of the use of magnetic catalysts for the synthesis of xanthine derivatives. The critical potential interest in the present method include short reaction time, high yields, recyclability of the catalyst, easy workup, and the ability to sustain a variety of functional groups, which give economical as well as ecological rewards. Also, the synthesized catalyst was used as a recyclable trinuclear catalyst in alcohol oxidation reactions at 40 °C. The magnetic catalyst activity of Fe3O4@NFC@NNSM-Mn(iii) could be attributed to the synergistic effects of the catalyst Fe3O4@NFC@NNS-Mn(iii) with melamine. Employing a sustainable and safe low temperature, using an eco-friendly solvent, no need to use any additive, and long-term stability and magnetic recyclability of the catalyst for at least six successive runs are the advantages of the current protocol towards green chemistry. This protocol is a benign, environmentally friendly method for heterocycle synthesis. This journal is

Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) employing p-toluenesulfonic acid (p-TSA) as a solid acid catalyst

Green synthesis of novel bis(hexahydro-1H-xanthene-1,8(2H)-diones) which are linked to aliphatic or aromatic spacers via ether or ester linkages were performed in good to excellent yields by the reaction of 5,5-dimethyl-1,3-cyclohexanedione with the appropriate bis-aldehydes using p-TSA as an organic acid solid catalyst. The reaction of the bis-aldehydes with barbituric acid or 1,3-dimethylbarbituric acid instead of 5,5-dimethyl-1,3-cyclohexanedione afforded the corresponding Knoevenagel condensation adducts in good yield.

BIVALENT LECA INHIBITORS TARGETING BIOFILM FORMATION OF PSEUDOMONAS AERUGINOSA

The present invention relates to divalent compounds binding to LecA. The compounds are useful to block biofilm formation of Pseudomonas aeruginosa. The invention further relates to pharmaceutical compositions comprising these compounds and to therapeutic methods and uses of these compounds, in particular to therapeutic methods and uses for the treatment of Pseudomonas aeruginosa infections in a subject. The invention also relates to imaging of infections, such as biofilms produced by Pseudomonas aeruginosa, by using these divalent compounds.

A rapid synthesis of low-nanomolar divalent LecA inhibitors in four linear steps from d-galactose pentaacetate

Chronic infections with Pseudomonas aeruginosa are associated with the formation of bacterial biofilms. The tetrameric P. aeruginosa lectin LecA is a virulence factor and an anti-biofilm drug target. Increasing the overall binding affinity by multivalent

Novel 2-cyanoacrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene derivatives as potent anticancer agents

Ethyl 2-acrylamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate as well as its corresponding bis-derivatives, 5–10, with aliphatic linkers were synthesized, fully characterized, and tested as novel anticancer agents. The targeted compounds, 5–10, wer

Polyethylene glycol-bonded triethylammonium l-prolinate: A new biodegradable amino-acid-based ionic liquid for the one-pot synthesis of bis(pyrazolyl)methanes as DNA binding agents

Polyethylene glycol-bonded triethylammonium l-prolinate ([PEG-TEA]LP) was prepared as a new, highly efficient, reusable and biodegradable amino-acid-based ionic liquid catalyst using cheap and easily accessible starting materials. The [PEG-TEA]LP chemical