SUC-ALA-ALA-PRO-VAL-PNA

Base Information

• Chemical Name: SUC-ALA-ALA-PRO-VAL-PNA
• CAS No.: 72682-76-9
• Molecular Formula: C26H36N6O9
• Molecular Weight: 576.607
• Mol file: 72682-76-9.mol

Synonyms:3-carboxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide;succinyl-Ala-Ala-Pro-Val-p-nitroanilide;

Chemical Property of SUC-ALA-ALA-PRO-VAL-PNA

Chemical Property:

• PSA: 219.83000
• LogP: 2.24610
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of SUC-ALA-ALA-PRO-VAL-PNA

There total 5 articles about SUC-ALA-ALA-PRO-VAL-PNA which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

succinic acid anhydride (108-30-5) + (S)-1-[(S)-2-((S)-2-Amino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-2-methyl-1-(4-nitro-phenylcarbamoyl)-propyl]-amide (90105-48-9) → 3-carboxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide (72682-76-9)

Guidance literature:

In acetonitrile; for 24h;

Reference yield:

benzyloxycarbonyl-L-alanyl-L-alanine (16012-70-7) → 3-carboxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide (72682-76-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 71 percent / 24 h / Ambient temperature

2: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature

3: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C

4: HBr / trifluoroacetic acid

5: 70 percent / acetonitrile / 24 h

With N-ethylmorpholine;; sodium hydroxide; hydrogen bromide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; acetonitrile; trifluoroacetic acid;

Reference yield:

N-carbpbenzoxy-alanine pentafluorophenyl ester (90105-39-8) → 3-carboxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide (72682-76-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 69 percent / 1N NaOH / dioxane / 24 h / Ambient temperature

2: 73 percent / N-ethylmorpholine, isobutyl chloroformate / tetrahydrofuran / 1 h / -15 - 20 °C

3: HBr / trifluoroacetic acid

4: 70 percent / acetonitrile / 24 h

With N-ethylmorpholine;; sodium hydroxide; hydrogen bromide; isobutyl chloroformate; In tetrahydrofuran; 1,4-dioxane; acetonitrile; trifluoroacetic acid;

upstream raw materials:

succinic acid anhydride

(S)-1-[(S)-2-((S)-2-Amino-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid [(S)-2-methyl-1-(4-nitro-phenylcarbamoyl)-propyl]-amide

benzyloxycarbonyl-L-alanyl-L-alanine

N-carbpbenzoxy-alanine pentafluorophenyl ester

Downstream raw materials:

4-nitro-aniline

N-3-carbomethoxypropanoyl-alanyl-alanyl-prolyl-valine p-nitroanilide