5-chloro-2,2-diphenylpentanenitrile

Base Information

• Chemical Name: 5-chloro-2,2-diphenylpentanenitrile
• CAS No.: 1585-11-1
• Molecular Formula: C17H16 Cl N
• Molecular Weight: 269.774
• Mol file: 1585-11-1.mol

Synonyms:Valeronitrile,5-chloro-2,2-diphenyl- (7CI,8CI); 5-Chloro-2,2-diphenylvaleronitrile; NSC287523

Chemical Property of 5-chloro-2,2-diphenylpentanenitrile

Chemical Property:

• Vapor Pressure: 3.44E-07mmHg at 25°C
• Boiling Point: 417.8°Cat760mmHg
• Flash Point: 183°C
• Density: 1.121g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-2,2-diphenylpentanenitrile

There total 4 articles about 5-chloro-2,2-diphenylpentanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Diphenylacetonitrile (86-29-3) + 1,3-Dichloropropane (142-28-9) → 5-chloro-2,2-diphenylpentanenitrile (1585-11-1)

Guidance literature:

Diphenylacetonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;

1,3-Dichloropropane; In N,N-dimethyl-formamide;

DOI:10.1021/jm050418d

Reference yield:

Diphenylacetonitrile (86-29-3) + 1.3-chlorobromopropane (109-70-6) → 5-chloro-2,2-diphenylpentanenitrile (1585-11-1) + 2,2,6,6-tetraphenylheptanedinitrile (1258-19-1)

Guidance literature:

Multistep reaction; (i) NaNH₂, dioxane, (ii) /BRN= 605278/, dioxane;

Reference yield:

Diphenylacetonitrile (86-29-3) + 1.3-chlorobromopropane (109-70-6) → 5-chloro-2,2-diphenylpentanenitrile (1585-11-1)

Guidance literature:

Multistep reaction; (i) NaNH₂, dioxane, (ii) /BRN= 605278/;

DOI:10.1021/jm00341a010

upstream raw materials:

Diphenylacetonitrile

1.3-chlorobromopropane

1,3-Dichloropropane

Downstream raw materials:

5-[4-(4-chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-pentanenitrile

1,6-Diimino-2,2,7,7-tetraphenyl-5,10-dicyan-cyclodecan

2,2-diphenyl-adipic acid dimethyl ester

2,2-diphenyl-adipic acid

Refernces

• 1、 Hulshof, Janneke W.,Casarosa, Paola,Menge, Wiro M. P. B.,Kuusisto, Leena M. S.,Van Der Goot, Henk,Smit, Martine J.,De Esch, Iwan J. P.,Leurs, Rob. "Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28". . p. 6461 - 6471. Retrieved 2007/10/03.