Halogenated aliphatic compounds, such as 1-Bromo-3-chloropropane, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
A colorless liquid. Insoluble in water and denser than water. May be toxic by inhalation, ingestion or skin absorption. Used to make pharmaceuticals and other chemicals.
Some of these materials may burn, but none ignite readily. Containers may explode when heated.
1-Bromo-3-chloropropane can be used safer and equally efficient alternative to chloroform as a phase-separation agent in the 1-step method of RNA isolation from biological samples such as animal and p
A replacement for CHCl3 in RNA phase separations
Wash it with conc H2SO4, water, 10% Na2CO3 solution, water again and then dry with CaCl2 and fractionally distil it just before use [Akagi et al. J Am Chem Soc 78 4034 1956]. [Beilstein 1 H 109, 1 IV 212.]
Air & Water Reactions
Insoluble in water.
Inhalation of vapors or dust is extremely irritating. May cause burning of eyes and flow of tears. May cause coughing, difficult breathing and nausea. Brief exposure effects last only a few minutes. Exposure in an enclosed area may be very harmful. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may cause pollution.