7-Hydroxy-4',5,6,8-tetramethoxyflavone

Base Information

Chemical Name:7-Hydroxy-4',5,6,8-tetramethoxyflavone
CAS No.:73213-66-8
Molecular Formula:C19H18O7
Molecular Weight:358.348
Hs Code.:
UNII:9DLD121996
Nikkaji Number:J470.639K
Wikidata:Q27272402
Metabolomics Workbench ID:24533

Synonyms:7-Hydroxy-4',5,6,8-tetramethoxyflavone;UNII-9DLD121996;9DLD121996;73213-66-8;7-Hydroxy-5,6,8-trimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;7-Hydroxy-5,6,8,4'-tetramethoxyflavone;7-Demethyltangeretin;7-hydroxy-5,6,8-trimethoxy-2-(4-methoxyphenyl)chromen-4-one;LMPK12111450;Q27272402;7-Hydroxy-2-(4-methoxyphenyl)-5,6,8-trimethoxy-4H-1-benzopyran-4-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-Hydroxy-4',5,6,8-tetramethoxyflavone

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:358.10525291
Heavy Atom Count:26
Complexity:526

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C(=C3OC)OC)O)OC

Technology Process of 7-Hydroxy-4',5,6,8-tetramethoxyflavone

There total 15 articles about 7-Hydroxy-4',5,6,8-tetramethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 6,8-dibromo-7-hydroxy-5,4′-dimethoxyflavone

: 124-41-4
sodium methylate

: 73213-66-8
7-hydroxy-5,6,8,4′-tetramethoxyflavone

Guidance literature:: With copper(I) bromide; In methanol; N,N-dimethyl-formamide; for 1h; Inert atmosphere; Microwave irradiation;
DOI:10.1007/s00044-017-1871-4

Reference yield:

: 56002-82-5
2,3-diacetoxy-1,4,5-trimethoxy-benzene

: 73213-66-8
7-hydroxy-5,6,8,4′-tetramethoxyflavone

Guidance literature:: Multi-step reaction with 11 steps

1: 77 percent / K₂CO₃ / acetone; dimethylformamide / 50 h / Heating

2: 10percent aq. NaOH / methanol / 0.5 h / Ambient temperature

3: K₂CO₃ / acetone / 3 h / Heating

4: H₂ / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature

5: pyridine

6: 1.) AcOH, BF₃(g), 2.) pyridine / 1.) from 50 to 60 deg C, 5 h

7: 10percent aq. NaOH / methanol / 0.25 h / Ambient temperature

8: (i-Pr)2NEt / CH₂Cl₂ / 0.83 h / 5 °C

9: pyridine / 3 h / 60 - 70 °C

10: KOH, pyridine / 2 h / 60 °C

11: conc. H₂SO₄, HOAc / 1 h / 50 °C

With pyridine; potassium hydroxide; sodium hydroxide; sulfuric acid; boron trifluoride; hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1246/bcsj.69.1033

Reference yield:

: 7507-98-4
1-(2-hydroxy-3,4,6-trimethoxyphenyl)ethanone

: 73213-66-8
7-hydroxy-5,6,8,4′-tetramethoxyflavone

Guidance literature:: Multi-step reaction with 13 steps

1: 4percent aq. NaOH, 6percent aq. H₂O₂ / methanol / 2 h / 50 °C

2: pyridine

3: 77 percent / K₂CO₃ / acetone; dimethylformamide / 50 h / Heating

4: 10percent aq. NaOH / methanol / 0.5 h / Ambient temperature

5: K₂CO₃ / acetone / 3 h / Heating

6: H₂ / 10percent Pd/C / methanol; ethyl acetate / Ambient temperature

7: pyridine

8: 1.) AcOH, BF₃(g), 2.) pyridine / 1.) from 50 to 60 deg C, 5 h

9: 10percent aq. NaOH / methanol / 0.25 h / Ambient temperature

10: (i-Pr)2NEt / CH₂Cl₂ / 0.83 h / 5 °C

11: pyridine / 3 h / 60 - 70 °C

12: KOH, pyridine / 2 h / 60 °C

13: conc. H₂SO₄, HOAc / 1 h / 50 °C

With pyridine; potassium hydroxide; sodium hydroxide; sulfuric acid; boron trifluoride; hydrogen; dihydrogen peroxide; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone;
DOI:10.1246/bcsj.69.1033