4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde

Base Information

• Chemical Name: 4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde
• CAS No.: 73279-02-4
• Molecular Formula: C18H15NO4
• Molecular Weight: 309.321
• Hs Code.: 2933998090
• DSSTox Substance ID: DTXSID00365803
• Wikidata: Q82150770
• Mol file: 73279-02-4.mol

Synonyms:73279-02-4;4-[3-(1,3-dioxoisoindol-2-yl)propoxy]benzaldehyde;4-(3-(1,3-Dioxoisoindolin-2-yl)propoxy)benzaldehyde;4-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propoxy]benzaldehyde;SCHEMBL3626811;DTXSID00365803;WACIDFSJZAPASS-UHFFFAOYSA-N;AKOS017118175;A1-05004;2-[3-[4-Formylphenoxy]propyl]-1H-isoindole-1,3-dione

Chemical Property of 4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde

Chemical Property:

• PSA: 63.68000
• LogP: 2.50210
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 309.10010796
• Heavy Atom Count: 23
• Complexity: 432

Purity/Quality:

4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CCCOC3=CC=C(C=C3)C=O

Technology Process of 4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde

There total 5 articles about 4-[3-(1,3-Dioxoisoindol-2-yl)propoxy]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.8%

2-(3-bromopropyl)isoindole-1,3-dione (5460-29-7) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-[3-[4-Formylphenoxy]propyl]-1H-isoindole-1,3-dione (73279-02-4)

Guidance literature:

DOI:10.1021/ja00162a066

Reference yield:

phthalimide (136918-14-4,85-41-6) → 2-[3-[4-Formylphenoxy]propyl]-1H-isoindole-1,3-dione (73279-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetone / 8 h / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 8 h / 80 °C

With potassium carbonate; In N,N-dimethyl-formamide; acetone;

DOI:10.1016/j.ejmech.2017.06.040

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 2-[3-[4-Formylphenoxy]propyl]-1H-isoindole-1,3-dione (73279-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide

2: potassium carbonate / N,N-dimethyl-formamide

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1002/jccs.202000215

upstream raw materials:

2-(3-bromopropyl)isoindole-1,3-dione

4-hydroxy-benzaldehyde

phthalimide

4-(3-bromopropoxy)benzaldehyde

Downstream raw materials:

[1N-(oxyproplyamine)-3,6,10,13,16,19-hexaazabicyclo[6.6.6]eicosane-1,8-diamine]

C₂₇H₃₂BF₂N₃OS

C₂₆H₃₄BF₂N₃O

C₃₆H₅₁BF₂N₅O₂S