2-[(4-Nitrophenyl)sulfanyl]pyridine

Base Information

• Chemical Name: 2-[(4-Nitrophenyl)sulfanyl]pyridine
• CAS No.: 73322-01-7
• Molecular Formula: C11H8N2O2S
• Molecular Weight: 232.263
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID90398802
• Wikidata: Q82200985
• Mol file: 73322-01-7.mol

Synonyms:73322-01-7;2-[(4-nitrophenyl)sulfanyl]pyridine;1-Nitro-4-(2-pyridylthio)benzene;2-(4-nitrophenyl)sulfanylpyridine;2-((4-Nitrophenyl)thio)pyridine;SCHEMBL177702;(4-nitrophenylsulfanyl) pyridine;DTXSID90398802;HOPZSPAIKGULRS-UHFFFAOYSA-N;2-(4-nitrophenyl)sulfanyl-pyridine;4-(2-pyridinylthio)-1-nitrobenzene;MFCD00170204;AKOS005110645;MS-6217;CS-0331194

Chemical Property of 2-[(4-Nitrophenyl)sulfanyl]pyridine

Chemical Property:

• PSA: 84.01000
• LogP: 3.66420
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 232.03064868
• Heavy Atom Count: 16
• Complexity: 237

Purity/Quality:

99% ^*data from raw suppliers

2-[(4-Nitrophenyl)sulfanyl]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)SC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of 2-[(4-Nitrophenyl)sulfanyl]pyridine

There total 16 articles about 2-[(4-Nitrophenyl)sulfanyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + 4-Fluoronitrobenzene (350-46-9,178603-76-4) → 2-((4-nitrophenyl)thio)pyridine (73322-01-7)

Guidance literature:

With copper(ll) sulfate pentahydrate; sodium carbonate; sodium L-ascorbate; L-proline; In water; dimethyl sulfoxide; at 70 ℃; for 12h;

DOI:10.1016/j.tet.2010.07.032

Reference yield: 84.0%

2-Sulfanylpyridine (2637-34-5,73018-10-7) + p-nitrobenzene iodide (636-98-6) → 2-((4-nitrophenyl)thio)pyridine (73322-01-7)

Guidance literature:

With 1-(4-nitrophenyl)-3-N,N-dimethylamino-2-propen-1-one; copper(II) acetate monohydrate; caesium carbonate; In dimethyl sulfoxide; at 100 ℃; for 12h;

DOI:10.1039/c4ra07187e

Reference yield: 80.0%

N-fluoropyridinium triflate (107263-95-6) + para-nitrobenzenethiol (1849-36-1) → 2-methoxypyridine (1628-89-3) + 2-((4-nitrophenyl)thio)pyridine (73322-01-7)

Guidance literature:

With sodium methylate; In methanol; a.) -78 deg C, 1 h, b.) -78 deg C - 23 deg C, 1 h, c.) 23 deg C, 2 h;

DOI:10.1002/jhet.5570300530

upstream raw materials:

pyridine-2-thione

4-chlorobenzonitrile

2-mercaptopyridine sodium salt

N-fluoropyridinium triflate

Downstream raw materials:

4-(pyridine-2-ylthio)-aniline

2-(4-nitrobenzenesulfonyl)-pyridine

2,2'-dipyridyldisulphide

di(p-nitrophenyl) disulfide