2-(4-Methoxyphenyl)isoindoline

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)isoindoline
• CAS No.: 73357-44-5
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• DSSTox Substance ID: DTXSID60357446
• Nikkaji Number: J938.880J
• Wikidata: Q82137348

Synonyms:2-(4-Methoxyphenyl)isoindoline;73357-44-5;2-(4-methoxyphenyl)-1,3-dihydroisoindole;Oprea1_441207;2-p-methoxyphenyl-isoindoline;1H-Isoindole, 2,3-dihydro-2-(4-methoxyphenyl)-;DTXSID60357446;STL363762;AKOS022118784;SB65664;CS-0364611;2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindole

Chemical Property of 2-(4-Methoxyphenyl)isoindoline

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 225.115364102
• Heavy Atom Count: 17
• Complexity: 233

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2CC3=CC=CC=C3C2

Technology Process of 2-(4-Methoxyphenyl)isoindoline

There total 4 articles about 2-(4-Methoxyphenyl)isoindoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-methoxy-aniline (104-94-9) + phthalyl alcohol (612-14-6) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindole (73357-44-5)

Guidance literature:

With caesium carbonate; In toluene; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1002/chem.201904095

Reference yield: 85.0%

4-methoxy-aniline (104-94-9) + o-phthalic dicarboxaldehyde (643-79-8) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindole (73357-44-5)

Guidance literature:

4-methoxy-aniline; o-phthalic dicarboxaldehyde; In methanol; at 25 ℃; for 1.5h;

With H₂SiEt₂; In methanol; at 25 ℃;

DOI:10.1002/ejoc.202000483

Reference yield: 72.0%

4-methoxy-aniline (104-94-9) + α,α'-dibromo-o-xylene (91-13-4) → 2-(4-methoxyphenyl)-2,3-dihydro-1H-isoindole (73357-44-5)

Guidance literature:

In N,N-dimethyl-formamide; for 3h; Heating;

upstream raw materials:

4-methoxy-aniline

α,α'-dibromo-o-xylene

o-phthalic dicarboxaldehyde

phthalyl alcohol

Downstream raw materials:

2-(4-Methoxy-phenyl)-2,3-dihydro-1H-isoindole; compound with 2,3,5,6-tetrabromo-[1,4]benzoquinone

2-(4-Methoxy-phenyl)-2,3-dihydro-1H-isoindole; compound with 2,3,5,6-tetrachloro-[1,4]benzoquinone

(Z)-2,2'-Bis-(4-methoxy-phenyl)-[1,1']biisoindolylidene-3,3'-dione

2-(4-methoxyphenyl)isoindoline-1,3-dione

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