10.1002/chem.202001439
The study presents a novel and practical method for ortho-selective C-H perfluoroalkylation, including trifluoromethylations, of anilines and indoles using ruthenium catalysis. The process is significant for the synthesis of various (per)fluoroalkylated building blocks, which are valuable for creating bioactive compounds and materials. The researchers utilized commercially available reagents RI and RfBr, achieving high site selectivity without the need for protecting groups. The methodology is attractive due to the availability and cost of the starting materials, and it offers a mild reaction condition for the direct C-H perfluoroalkylation of anilines. The study also explores the substrate scope and reaction conditions, demonstrating the potential for gram-scale synthesis and the successful application to indoles, providing a pathway to selectively functionalize these important heterocyclic compounds.
10.3184/174751912X13460810792101
The research focuses on developing a green and efficient method for the acylation of amines and phenols using hydrotalcite as a catalyst in water at room temperature. The study aimed to overcome the disadvantages of traditional methods, such as the use of toxic solvents and complicated reaction conditions, by following the principles of green chemistry. The experiments involved the reaction of various amines and phenols with carboxylic acid anhydrides and chlorides, using different amounts of water and catalyst to optimize the reaction conditions. The reactants included 4-methoxyaniline, 4-nitrobenzoyl chloride, and other substituted amines and phenols, along with acetylating agents like acetic anhydride and benzoic anhydride. The analyses used to characterize the products included Fourier-transform infrared spectroscopy (FT-IR), proton (1H) and carbon (13C) nuclear magnetic resonance (NMR) spectroscopy. The results showed that the method was effective, yielding moderate to high yields of amides and esters with good purity, and the catalyst could be reused without significant loss of activity.
T+; 
N; 
Xi
