7,8-Dimethoxyflavanone

Base Information

• Chemical Name: 7,8-Dimethoxyflavanone
• CAS No.: 73413-67-9
• Molecular Formula: C17H16O4
• Molecular Weight: 284.30700
• DSSTox Substance ID: DTXSID40572958
• Metabolomics Workbench ID: 27255
• Nikkaji Number: J837.943B
• Wikidata: Q82461502
• Mol file: 73413-67-9.mol

Synonyms:7,8-Dimethoxyflavanone;73413-67-9;7,8-Dimethoxy-2-phenylchroman-4-one;7,8-dimethoxy-2-phenyl-2,3-dihydrochromen-4-one;7,8-dimethoxy-2-phenyl-3,4-dihydro-2H-1-benzopyran-4-one;7,8-Dimethoxyflavanon;DTXSID40572958;LMPK12140090;7,8-Dimethoxy-2-phenyl-2,3-dihydro-4H-1-benzopyran-4-one

Chemical Property of 7,8-Dimethoxyflavanone

Chemical Property:

• PSA: 44.76000
• LogP: 3.41030
• XLogP3: 2.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 284.10485899
• Heavy Atom Count: 21
• Complexity: 364

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C2=C(C=C1)C(=O)CC(O2)C3=CC=CC=C3)OC

Technology Process of 7,8-Dimethoxyflavanone

There total 8 articles about 7,8-Dimethoxyflavanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

7,8-dihydroxyflavanone (51876-18-7) + dimethyl sulfate (77-78-1) → 7,8-dimethoxyflavanone (73413-67-9)

Guidance literature:

With potassium carbonate; In acetone; at 25 ℃; for 24h;

DOI:10.1016/j.tet.2010.06.014

Reference yield: 90.0%

3',4'-Dimethoxy-2'-hydroxychalcone (82964-34-9) → 7,8-dimethoxyflavanone (73413-67-9)

Guidance literature:

With hydrogenchloride; In ethanol;

Reference yield:

2'-hydroxy-3',4'-dimethoxyacetophenone (5396-18-9) → 7,8-dimethoxyflavanone (73413-67-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / KOH / methanol / 24 h / 20 °C

2: 82 percent / pyridine / methanol; H₂O / 12 h / Heating

With pyridine; potassium hydroxide; In methanol; water; 1: Claisen condensation;

upstream raw materials:

3',4'-Dimethoxy-2'-hydroxychalcone

2'-hydroxy-3',4'-dimethoxyacetophenone

benzaldehyde

(E)-3-phenylacrylic acid

Downstream raw materials:

7,8-dimethoxy-isoflavone

7,8-dimethoxyflavone