51876-18-7

Usage

Uses

Used in Pharmaceutical Industry:
7,8-DIHYDROXYFLAVANONE is used as a pharmaceutical compound for its antineoplastic activity. It inhibits the formation of Jun-Fos-DNA complex, which plays a role in the regulation of cell proliferation and differentiation, making it a potential candidate for cancer treatment.
Used in Anticancer Applications:
7,8-DIHYDROXYFLAVANONE is used as an anticancer agent, targeting various types of cancer by inhibiting the Jun-Fos-DNA complex formation. This inhibition can potentially lead to the suppression of tumor growth and the prevention of cancer progression.
Used in Drug Development:
7,8-DIHYDROXYFLAVANONE can be used as a starting material or a key intermediate in the development of new drugs targeting cancer and other related diseases. Its unique chemical structure and biological activity make it a valuable compound for further research and development in the pharmaceutical industry.

Upstream product

• 82964-32-7 RLc₁₁ 
• 528-21-2 2',3',4'-trihydroxyacetophenone 
• 140-10-3 (E)-3-phenylacrylic acid 
• 6515-36-2 7-hydroxy-2-phenyl-chroman-4-one 
• 87-66-1 2-hydroxyresorcinol 
• 82964-28-1 2'-(difluoroboryloxy)-3',4'-dihydroxychalcone 
• 100-52-7 benzaldehyde 

Downstream Products

• 73413-67-9 7,8-dimethoxyflavanone 

Relevant academic research and scientific papers

Selective and efficient oxidative modifications of flavonoids with 2-iodoxybenzoic acid (IBX)

2-Iodoxybenzoic acid (IBX), a mild and efficient hypervalent iodine oxidant, has been utilised in different reaction conditions to perform several efficient oxidative modifications of flavonoids. Fine-tuning of the reaction conditions allowed remarkably selective modifications of these compounds. At room temperature, IBX proved to be an excellent reagent for a highly regioselective aromatic hydroxylation of monohydroxylated flavanones and flavones, generating the corresponding catecholic derivatives showing high antioxidant activity. At 90 °C, IBX efficiently dehydrogenated a large panel of methoxylated flavanones to their corresponding flavones exhibiting anticancer activity. IBX polystyrene has also been utilised to increase the recovery of highly polar compounds. Following the first oxidation, the reagent was recovered and reused in several runs without loss of efficiency and selectivity. The first example of an application of IBX polystyrene in a dehydrogenation reaction has been described.

Flavonoids: Structural requirements for antiproliferative activity on breast cancer cells

Several classes of flavonoids (flavones, flavanones, 2′-hydroxychalcones and flavan-4-ols) having a variety of substituents on A ring were investigated for their antiproliferative activity against MCF-7 human breast cancer cells. Structure-activity relationships of these compounds were discussed. 2′-hydroxychalcones and methoxylated flavanones were found to be potent inhibitors of MCF-7 cells growth whereas flavones and flavan-4-ols appeared to be weak inhibitory agents except 7,8-dihydroxyflavone.