Dimethyl trans-(+)-1,2-cyclobutanedicarboxylate

Base Information

• Chemical Name: Dimethyl trans-(+)-1,2-cyclobutanedicarboxylate
• CAS No.: 7371-67-7
• Molecular Formula: C8H12O4
• Molecular Weight: 172.181
• Mol file: 7371-67-7.mol

Synonyms:dimethyl trans-1,2-cyclobutanedicarboxylate;trans-1,2-cyclobutane dimethylcarboxylate;trans-1,2-cyclobutanedicarboxylic acid,dimethyl ester;(+/-)-trans-Cyclobutan-dicarbonsaeure-(1.2)-dimethylester;1,2-Cyclobutanedicarboxylic acid, dimethyl ester, trans-;dimethyl trans-cyclobutane-1,2-dicarboxylate;(+/-)-trans-cyclobutane-dicarboxylic acid-(1.2)-dimethyl ester;

Chemical Property of Dimethyl trans-(+)-1,2-cyclobutanedicarboxylate

Chemical Property:

• Refractive Index: 1.4450 (estimate)
• Boiling Point: 225°C (estimate)
• PSA: 52.60000
• Density: 1.1276
• LogP: 0.35860

Purity/Quality:

95% ^*data from raw suppliers

1,2-Cyclobutanedicarboxylicacid,dimethylester,trans- 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Dimethyl trans-(+)-1,2-cyclobutanedicarboxylate

There total 1 articles about Dimethyl trans-(+)-1,2-cyclobutanedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cis-1,2-cyclobutane dicarboxylic anhydride (4462-96-8) + sodium methylate (124-41-4) → dimethyl trans-1,2-cyclobutane dicarboxylate (7371-67-7)

Guidance literature:

With sulfuric acid; Yield given. Multistep reaction; 1.) CH₃OH, reflux, 6 h, 2.) CH₃OH, reflux, 12 h;

DOI:10.1021/ja00381a024

Reference yield: 88.0%

dimethyl trans-1,2-cyclobutane dicarboxylate (7371-67-7) → trans-(cyclobutane-1,2-diyl)dimethanol (7371-64-4,54445-64-6,55659-54-6,82442-57-7,82442-58-8,5140-07-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/ja00381a024

Reference yield:

dimethyl trans-1,2-cyclobutane dicarboxylate (7371-67-7) → trans-1,2-cyclobutanedimethanol, bis(toluenesulfonate) (35630-06-9,55641-14-0,76497-45-5,110269-37-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / LiALH₄ / tetrahydrofuran

2: 69 percent

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1021/ja00256a040

upstream raw materials:

cis-1,2-cyclobutane dicarboxylic anhydride

sodium methylate

Downstream raw materials:

(+/-)-trans-cyclobutane-dicarboxylic acid-(1.2)-diamide

trans-(cyclobutane-1,2-diyl)dimethanol

methyl trans-2-(cyanomethyl)cyclobutanecarboxylate

trans-1,2-cyclobutanedimethanol, bis(toluenesulfonate)

Refernces