1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

Base Information

Chemical Name:1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine
CAS No.:73735-69-0
Molecular Formula:C₂₆H₂₈FN₅
Molecular Weight:429.54
Hs Code.:
DSSTox Substance ID:DTXSID30437360
Nikkaji Number:J395.134K
Wikidata:Q82252849
ChEMBL ID:CHEMBL60852
Mol file:73735-69-0.mol

Synonyms:73735-69-0;1-[(4-Fluorophenyl)methyl]-N-[1-[2-(2-pyridinyl)ethyl]-4-piperidinyl]-1H-benzimidazol-2-amine;1-[(4-fluorophenyl)methyl]-N-{1-[2-(2-pyridinyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine;CHEMBL60852;SCHEMBL11480928;DTXSID30437360;NPSCMXULOBAGPB-UHFFFAOYSA-N;1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

Suppliers and Price of 1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

Chemical Property:

XLogP3:5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:429.23287408
Heavy Atom Count:32
Complexity:560

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCC1NC2=NC3=CC=CC=C3N2CC4=CC=C(C=C4)F)CCC5=CC=CC=N5

Technology Process of 1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine

There total 4 articles about 1-[(4-Fluorophenyl)methyl]-N-{1-[2-(pyridin-2-yl)ethyl]piperidin-4-yl}-1H-benzimidazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-69-6,25014-15-7,27476-03-5,329041-71-6
2-vinylpyridine

: 67-66-3,8013-54-5
chloroform

: 75970-99-9
norastemizole

: 71-36-3
butan-1-ol

: 73735-69-0
1-[(4-fluorophenyl)methyl]-N-{1-[2-(2-pyridinyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine

Guidance literature:: In methanol;

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 73735-69-0
1-[(4-fluorophenyl)methyl]-N-{1-[2-(2-pyridinyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: 23 percent / butan-1-ol

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 73735-69-0
1-[(4-fluorophenyl)methyl]-N-{1-[2-(2-pyridinyl)ethyl]-4-piperidinyl}-1H-benzimidazol-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: 23 percent / butan-1-ol

With hydrogen bromide; In butan-1-ol;
DOI:10.1021/jm00150a029