Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d] pyrimidin-6-yl]phenyl]-N'-methoxy-

Base Information

Chemical Name:Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d] pyrimidin-6-yl]phenyl]-N'-methoxy-
CAS No.:737790-70-4
Molecular Formula:C₃₂H₃₂F₂N₆O₆S
Molecular Weight:666.705
Hs Code.:

Urea,
N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth
yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d]
pyrimidin-6-yl]phenyl]-N'-methoxy-

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Chemical Property of Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d] pyrimidin-6-yl]phenyl]-N'-methoxy-

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Technology Process of Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d] pyrimidin-6-yl]phenyl]-N'-methoxy-

There total 9 articles about Urea, N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d] pyrimidin-6-yl]phenyl]-N'-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₄H₃₈F₂N₆O₇S

: 737790-70-4
1-{4-[1-(2,6-difluorobenzyl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}-3-(6-methoxypyridin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea

Guidance literature:: With sodium methylate; In methanol; at 20 ℃; for 2h;
DOI:10.1021/jm200216q

Reference yield:

: 308831-93-8
2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

: 737790-70-4
1-{4-[1-(2,6-difluorobenzyl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}-3-(6-methoxypyridin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 44 h / 20 °C

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 67 h / 20 °C

5.2: 0 - 20 °C

6.1: sodium hydroxide / ethanol / 5 h / 60 °C

7.1: diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

8.1: sodium methylate / methanol / 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q

Reference yield:

: 308831-94-9
2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

: 737790-70-4
1-{4-[1-(2,6-difluorobenzyl)-5-{[(2-methoxyethyl)(methyl)amino]methyl}-3-(6-methoxypyridin-3-yl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl]phenyl}-3-methoxyurea

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 67 h / 20 °C

4.2: 0 - 20 °C

5.1: sodium hydroxide / ethanol / 5 h / 60 °C

6.1: diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice

7.1: sodium methylate / methanol / 2 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium methylate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q