Technology Process of Urea,
N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth
yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d]
pyrimidin-6-yl]phenyl]-N'-methoxy-
There total 9 articles about Urea,
N-[4-[1-[(2,6-difluorophenyl)methyl]-1,2,3,4-tetrahydro-5-[[(2-methoxyeth
yl)methylamino]methyl]-3-(6-methoxy-3-pyridinyl)-2,4-dioxothieno[2,3-d]
pyrimidin-6-yl]phenyl]-N'-methoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium methylate;
In
methanol;
at 20 ℃;
for 2h;
DOI:10.1021/jm200216q
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 44 h / 20 °C
2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr
5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 67 h / 20 °C
5.2: 0 - 20 °C
6.1: sodium hydroxide / ethanol / 5 h / 60 °C
7.1: diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice
8.1: sodium methylate / methanol / 2 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; N-ethyl-N,N-diisopropylamine; potassium iodide; sodium hydroxide;
In
methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / 3.5 h / Reflux
2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C
3.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / diethyl ether; ethanol / 1 h / 20 °C / 760.05 Torr
4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 67 h / 20 °C
4.2: 0 - 20 °C
5.1: sodium hydroxide / ethanol / 5 h / 60 °C
6.1: diethyl cyanophosphonate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C / Cooling with ice
7.1: sodium methylate / methanol / 2 h / 20 °C
With
hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); diethyl cyanophosphonate; palladium 10% on activated carbon; hydrogen; sodium methylate; N-ethyl-N,N-diisopropylamine; sodium hydroxide;
In
methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm200216q
