2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester
• CAS No.: 308831-93-8
• Molecular Formula: C₁₇H₁₈N₂O₆S
• Molecular Weight: 378.406

Synonyms:2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

Chemical Property of 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

Chemical Property:

• Boiling Point: 478.7±45.0 °C(Predicted)
• Density: 1.338±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

ethyl2-(ethoxycarbonylamino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

There total 5 articles about 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

chloroformic acid ethyl ester (541-41-3) + 2-Amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester (174072-89-0) → 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester (308831-93-8)

Guidance literature:

In toluene; for 12h; Reflux;

DOI:10.1021/jm200216q

Reference yield:

(E/Z)-2-cyano-3-methyl-4-(4-nitrophenyl)but-2-enoic acid ethyl ester (1313714-59-8) → 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester (308831-93-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfur; diethylamine / ethanol / 3.25 h / 65 °C

2: pyridine / dichloromethane / 2 h / 25 °C

With pyridine; sulfur; diethylamine; In ethanol; dichloromethane;

Reference yield:

1-(4-nitrophenyl)propan-2-one (5332-96-7) → 2-((ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester (308831-93-8)

Guidance literature:

Multi-step reaction with 3 steps

1: oenanthic acid; benzylamine / toluene / 12 h / 130 °C

2: sulfur; diethylamine / ethanol / 3.25 h / 65 °C

3: pyridine / dichloromethane / 2 h / 25 °C

With pyridine; oenanthic acid; sulfur; diethylamine; benzylamine; In ethanol; dichloromethane; toluene;

upstream raw materials:

chloroformic acid ethyl ester

2-Amino-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

1-(4-nitrophenyl)propan-2-one

ethyl 2-cyanoacetate

Downstream raw materials:

2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-methyl-5-(4-nitrophenyl)thiophene-3-carboxylic acid ethyl ester

ethyl 2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylate

2-((2,6-difluorobenzyl)(ethoxycarbonyl)amino)-4-((dimethylamino)methyl)-5-(4-nitrophenyl)thiophene-3-carboxylic acid

TAK-385

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