Technology Process of Glycine, N-[N-[(phenylmethoxy)carbonyl]-D-alanyl]-, 1,1-dimethylethyl
ester
There total 1 articles about Glycine, N-[N-[(phenylmethoxy)carbonyl]-D-alanyl]-, 1,1-dimethylethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
4-methyl-morpholine; triethylamine; isobutyl chloroformate;
Yield given. Multistep reaction;
1.) THF,-15 deg C, 2 min, 2.) THF, 0 deg C, 30 min; r.t., 4 h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 90percent aq. trifluoroacetic acid / 1 h / Ambient temperature
2: 78 percent / methanol
3: 1.) isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, DMF, -15 deg C, 2 min, 2.) THF, DMF, 0 deg C, 30 min; r.t., 48 h
4: H2 / 10percent Pd/C / methanol / Ambient temperature
5: 55 percent / tetrahydrofuran / 48 h / Ambient temperature
With
4-methyl-morpholine; hydrogen; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90percent aq. trifluoroacetic acid / 1 h / Ambient temperature
2: 78 percent / methanol
3: 1.) isobutyl chloroformate, 2.) N-methylmorpholine / 1.) THF, DMF, -15 deg C, 2 min, 2.) THF, DMF, 0 deg C, 30 min; r.t., 48 h
4: H2 / 10percent Pd/C / methanol / Ambient temperature
5: 55 percent / tetrahydrofuran / 48 h / Ambient temperature
6: 62 percent / hydrazine hydrate / methanol / 120 h / Ambient temperature
With
4-methyl-morpholine; hydrogen; hydrazine hydrate; trifluoroacetic acid; isobutyl chloroformate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol;
