26607-51-2Relevant articles and documents
Synthesis method of silodosin
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Paragraph 0068; 0086-0088, (2021/07/24)
The invention discloses a synthesis method of silodosin. The synthesis method comprises the following steps of: sequentially performing amino protection, bromination and deprotection on indoline serving as a raw material; carrying out an SN2 reaction to o
A palladium nanoparticle-nanomicelle combination for the stereo-selective semihydrogenation of alkynes in water at room temperature
Slack, Eric D.,Gabriel, Christopher M.,Lipshutz, Bruce H.
supporting information, p. 14051 - 14054 (2015/02/19)
The addition of NaBH4 to Pd(OAc) 2 in water containing nanomicelles leads to the generation of H2 and Pd nanoparticles. Subsequent reduction of disubstituted alkynes affords Z-alkenes in high yields. These reactions are general, take place in water at ambient temperatures, and offer recycling of the aqueous reaction mixture along with low overall E Factors.
Regioselective double Boekelheide reaction: First synthesis of 3,6-dialkylpyrazine-2,5-dicarboxaldehydes from dl-alanine
Das, Sajal Kumar,Frey, Joseph
scheme or table, p. 3869 - 3872 (2012/08/14)
Pyrazine-2,5-dicarboxaldehyde was synthesized on a multi-gram scale by MnO2 oxidation of 2,5-bis(hydroxymethyl)pyrazine, which in turn was obtained from 2,5-dimethylpyrazine employing double Boekelheide reaction as a key step as reported previously. This reaction was subsequently utilized in a regioselective fashion as a key step to synthesize efficiently, for the first time, 3,6-di(long-chain)alkylpyrazine-2,5-dicarboxaldehydes starting from dl-alanine. These monomers are certain to have importance as electron deficient and chemically versatile components for new materials development.
