N-(4-nitrophenyl)-N-phenylacetamide

Base Information

• Chemical Name: N-(4-nitrophenyl)-N-phenylacetamide
• CAS No.: 7418-39-5
• Molecular Formula: C14H12N2O3
• Molecular Weight: 256.261
• DSSTox Substance ID: DTXSID001294682
• Mol file: 7418-39-5.mol

Synonyms:N-(4-nitrophenyl)-N-phenylacetamide;DTXSID001294682;7418-39-5

Chemical Property of N-(4-nitrophenyl)-N-phenylacetamide

Chemical Property:

• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 256.08479225
• Heavy Atom Count: 19
• Complexity: 326

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)N(C1=CC=CC=C1)C2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of N-(4-nitrophenyl)-N-phenylacetamide

There total 12 articles about N-(4-nitrophenyl)-N-phenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

[(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate] (905718-45-8) + Acetanilid (103-84-4) → N-(4-nitrophenyl)-N-phenylacetamide (7418-39-5)

Guidance literature:

With sodium hydride; In toluene; mineral oil; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.orglett.5b01079

Reference yield: 96.0%

Acetanilid (103-84-4) + para-nitrophenyl bromide (586-78-7) → N-(4-nitrophenyl)-N-phenylacetamide (7418-39-5)

Guidance literature:

With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 24h; Catalytic behavior; Reflux;

DOI:10.1039/c4gc00558a

Reference yield: 87.0%

iodobenzene (591-50-4) + N-(4-Nitrophenyl)acetamide (104-04-1) → N-(4-nitrophenyl)-N-phenylacetamide (7418-39-5)

Guidance literature:

With potassium phosphate; copper(l) iodide; N,N`-dimethylethylenediamine; In 1,4-dioxane; at 110 ℃; for 9.5h; Inert atmosphere; Sealed tube;

DOI:10.1016/j.tetlet.2018.05.037

upstream raw materials:

N,N-diphenylacetamide

4-ntrophenyl(phenyl)amine

acetic anhydride

Acetanilid

Downstream raw materials:

4-nitrophenyldiphenylamine

4-ntrophenyl(phenyl)amine