n-[(1r)-2-Hydroxy-1-phenylethyl]benzamide

Base Information

• Chemical Name: n-[(1r)-2-Hydroxy-1-phenylethyl]benzamide
• CAS No.: 74213-58-4
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• DSSTox Substance ID: DTXSID80556691
• Nikkaji Number: J63.127B
• Wikidata: Q82438343
• Mol file: 74213-58-4.mol

Synonyms:n-[(1r)-2-hydroxy-1-phenylethyl]benzamide;74213-58-4;SCHEMBL9848822;DTXSID80556691;(R)-N-(2-Hydroxy-1-phenylethyl)benzamide;V10324

Chemical Property of n-[(1r)-2-Hydroxy-1-phenylethyl]benzamide

Chemical Property:

• XLogP3: 2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 241.110278721
• Heavy Atom Count: 18
• Complexity: 255

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CO)NC(=O)C2=CC=CC=C2
• Isomeric SMILES: C1=CC=C(C=C1)[C@H](CO)NC(=O)C2=CC=CC=C2

Technology Process of n-[(1r)-2-Hydroxy-1-phenylethyl]benzamide

There total 16 articles about n-[(1r)-2-Hydroxy-1-phenylethyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,4-diphenyl-Δ2-oxazoline (155242-42-5) → N-[(1R)-2-hydroxy-1-phenylethyl]benzamide (74213-58-4)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 50 ℃; for 1h;

DOI:10.1021/ja201543h

Reference yield: 93.0%

2-diazo-1,3-diphenylpropane-1,3-dione (2085-31-6) + D-2-phenylglycinol (56613-80-0) → N-[(1R)-2-hydroxy-1-phenylethyl]benzamide (74213-58-4)

Guidance literature:

In ethyl acetate; at 20 - 50 ℃; for 4h;

Reference yield: 72.0%

(R)-N-(2-((4-methoxybenzyl)oxy)-1-phenylethyl)benzamide (1575722-54-1) → N-[(1R)-2-hydroxy-1-phenylethyl]benzamide (74213-58-4)

Guidance literature:

With proton-exchanged montmorillonite; In dichloromethane; at 20 ℃;

DOI:10.1016/j.tet.2014.01.064

upstream raw materials:

N-benzoyl-(S)-phenylglycinal

D-2-phenylglycinol

benzoyl chloride

(S)-2-phenylglycine

Downstream raw materials:

2,4-diphenyl-Δ²-oxazoline

(R)-N-benzyl-2-phenylglycinol

N-(1-phenyl-2-phenylsulfanyl-ethyl)-benzamide

(R)-N-(2-((4-methoxybenzyl)oxy)-1-phenylethyl)benzamide