N-benzoyl-(S)-phenylglycinal

Base Information

• Chemical Name: N-benzoyl-(S)-phenylglycinal
• CAS No.: 163010-72-8
• Molecular Formula: C₁₅H₁₃NO₂
• Molecular Weight: 239.274
• Mol file: 163010-72-8.mol

Synonyms:N-benzoyl-(S)-phenylglycinal

Chemical Property of N-benzoyl-(S)-phenylglycinal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzoyl-(S)-phenylglycinal

There total 10 articles about N-benzoyl-(S)-phenylglycinal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

(-)-N-((S)-2-hydroxy-1-phenylethyl)benzamide (116126-04-6) → N-benzoyl-(S)-phenylglycinal (163010-72-8)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; water; at 23 ℃; for 0.5h;

DOI:10.1016/S0957-4166(02)00656-0

Reference yield:

(S)-N-(2,2-diethoxy-1-phenylethyl)benzamide → N-benzoyl-(S)-phenylglycinal (163010-72-8)

Guidance literature:

With hydrogenchloride; In water; acetone; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1039/d1cc06601c

Reference yield:

2,2-diethoxyacetophenone (6175-45-7) → N-benzoyl-(S)-phenylglycinal (163010-72-8)

Guidance literature:

Multi-step reaction with 3 steps

1: Ru(OAc)₂(S)-DTBM-SEGPHOS; ammonium acetate; hydrogen / 2,2,2-trifluoroethanol / 20 h / 90 °C / 38002.6 Torr / Autoclave

2: triethylamine / dichloromethane / 20 °C / Inert atmosphere

3: hydrogenchloride / acetone; water / 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; ammonium acetate; hydrogen; Ru(OAc)₂(S)-DTBM-SEGPHOS; triethylamine; In dichloromethane; 2,2,2-trifluoroethanol; water; acetone;

DOI:10.1039/d1cc06601c

upstream raw materials:

(-)-N-((S)-2-hydroxy-1-phenylethyl)benzamide

(S)-benzoylamino-phenyl-acetic acid methyl ester

(S)-2-phenylglycine

(2S)-2-phenylglycinol

Downstream raw materials:

N-((1S,2R)-2-hydroxy-1-phenyl-3-butenyl)benzamide

(-)-N-((1S,2S)-2-hydroxy-1-phenyl-3-butenyl)benzamide

N-[(1R)-2-hydroxy-1-phenylethyl]benzamide

(-)-N-((S)-2-hydroxy-1-phenylethyl)benzamide