7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Base Information

Chemical Name:7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid
CAS No.:74274-70-7
Molecular Formula:C₂₂H₂₃FN₄O₃
Molecular Weight:410.448
Hs Code.:
ChEMBL ID:CHEMBL322022
DSSTox Substance ID:DTXSID50535019
Nikkaji Number:J768.266B
Wikidata:Q82409096
Mol file:74274-70-7.mol

Synonyms:74274-70-7;7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;CHEMBL322022;DTXSID50535019

Suppliers and Price of 7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
7-(4-BENZYLPIPERAZIN-1-YL)-1-ETHYL-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 95.00%
5MG
$ 495.23

Total 0 raw suppliers

Chemical Property of 7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

Chemical Property:

PSA：95.74000
LogP:0.92510
XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:3
Exact Mass:362.13903326
Heavy Atom Count:26
Complexity:632

Purity/Quality:: 7-(4-BENZYLPIPERAZIN-1-YL)-1-ETHYL-6-FLUORO-4-OXO-1,8-NAPHTHYRIDINE-3-CARBOXYLIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C=C(C(=O)C2=CC(=C(N=C21)N3CCN(CC3)C(=O)C)F)C(=O)O

Technology Process of 7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

There total 9 articles about 7-(4-Acetylpiperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.7%

: 2759-28-6
1-phenylmethylpiperazine

: 79286-73-0
1-ethyl-1,4-dihydro-4-oxo-6-fluoro-7-chloro-1,8-naphthyridine-3-carboxylic acid

: 74274-70-7
7-(4-Benzyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: In acetonitrile; for 1h; Heating;
DOI:10.1021/jm00369a011

Reference yield:

: 87939-09-1
1-ethyl-6-fluoro-1,4-dihydro-7-hydroxy-4-oxo-1,8-naphthyridine-3-carboxylic acid

: 74274-70-7
7-(4-Benzyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 91.4 percent / POCl₃ / 0.25 h / Heating

2: 31.7 percent / acetonitrile / 1 h / Heating

With trichlorophosphate; In acetonitrile;
DOI:10.1021/jm00369a011

Reference yield:

: 82671-13-4
ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate

: 74274-70-7
7-(4-Benzyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / 20percent NaOH / 43 h / Heating

2: 91.4 percent / POCl₃ / 0.25 h / Heating

3: 31.7 percent / acetonitrile / 1 h / Heating

With sodium hydroxide; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm00369a011