79286-73-0

Upstream product

• 110919-75-0 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(trichloromethyl)-1,8-naphthyridine-3-carboxylic acid 
• 110919-72-7 diethyl <<(5-fluoro-6-methyl-2-pyridinyl)amino>methylene>propanedioate 
• 110919-74-9 ethyl 1-ethyl-6-fluoro-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate 
• 99726-90-6 1-ethyl-6-fluoro-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 110919-73-8 ethyl 6-fluoro-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylate 
• 110919-70-5 N-(5-fluoro-6-methyl-2-pyridinyl)acetamide 
• 110919-71-6 2-amino-5-fluoro-6-methylpyridine 
• 5671-67-0 N-(5-amino-6-methyl-2-pyridinyl)acetamide 
• 87938-98-5 C₁₉H₂₃N₆O₄⁽¹⁺⁾*F₆P^(1-) 
• 87939-04-6 7-(4-Acetyl-piperazin-1-yl)-1-ethyl-6-nitro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 87938-96-3 7-(4-Acetyl-piperazin-1-yl)-6-amino-1-ethyl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 54132-41-1 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 56654-05-8 ethyl 7-chloro-1-ethyl-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 
• 82671-13-4 ethyl 7-(4-acetyl-1-piperazinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylate 

Downstream Products

• 74274-64-9 1-Ethyl-6-fluoro-7-morpholin-4-yl-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 74274-66-1 N-methylenoxacin 
• 74274-67-2 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(4-ethyl-1-piperazinyl)-1,8-naphthyridine-3-carboxylic acid 
• 87939-12-6 Oxoenoxacin 
• 87939-25-1 1-Ethyl-6-fluoro-4-oxo-7-(4-phenyl-piperazin-1-yl)-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 91188-27-1 1-ethyl-6-fluoro-1,4-dihydro-7-(7-methyl-2,7-diazaspiro[ 4.4]non-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 91188-29-3 1-ethyl-6-fluoro-1,4-dihydro-7-(2,8-diazaspiro[5.5]undec-2-yl)-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 91187-82-5 1-ethyl-6-fluoro-1,4-dihydro-7-[3-[(methylamino)-methyl]-1-pyrrolidinyl]-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 79286-77-4 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 79286-76-3 7-(3-amino-1-pyrrolidinyl)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride 
• 92242-40-5 7-(4-Benzoylamino-piperidin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid ethyl ester 
• 92242-65-4 7-(4-Benzoylamino-piperidin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 
• 79286-80-9 7-[3-(N-methylacetamido)-1-pyrrolidinyl]-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid 
• 74274-70-7 7-(4-Benzyl-piperazin-1-yl)-1-ethyl-6-fluoro-4-oxo-1,4-dihydro-[1,8]naphthyridine-3-carboxylic acid 

Relevant academic research and scientific papers

Pyridonecarboxylic acids as antibacterial agents. 2. Synthesis and structure-activity relationships of 1,6,7-trisubstituted 1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids, including enoxacin, a new antibacterial agent

The title compounds having nitro, amino, cyano, chloro, or fluoro as the C-6 substituent were prepared. Introduction of the chloro and cyano groups at C-6 was accomplished by the Sandmeyer reaction of 6-amino-1,8-naphthyridine derivatives via their 6-diaz

Naphthyridine derivatives

The present invention provides a 1,8-naphthyridine compound of the formula STR1 wherein R is hydrogen, methyl, ethyl or propyl, and a nontoxic pharmaceutically acceptable salt thereof, and a process for preparing a 1,8-naphthyridine compound of the above formula which comprises (A) reacting a compound of the formula STR2 wherein Y is halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, lower alkylsulfonyloxy or arylsulfonyloxy, and R1 is hydrogen or lower alkyl, with a compound of the formula STR3 wherein R2 is hydrogen or a protective group for the amino group, and R is as defined above, and when a reaction product in which R1 is lower alkyl and/or R2 is the amino protective group is obtained, treating it with an acid or base, and/or reductively cleaving it, (B) decomposing a compound of the formula STR4 wherein A ? is a fluorine-containing anion, and R1 and R2 are as defined above, and when a reaction product in which R1 is lower alkyl and/or R2 is the amino protective group is obtained, treating it with an acid or base, and/or reductively cleaving it, (C) treating a compound of the formula STR5 wherein R'1 is hydrogen or lower alkyl, R'2 is hydrogen or a protective group for the amino group, provided that R'1 and R'2 are not hydrogen atoms at the same time, and R is as defined above, with an acid or base, and/or reductively cleaving it, and optionally converting the resulting compound to a nontoxic pharmaceutically acceptable salt thereof. The 1,8-naphthyridine compound is useful as an antibacterial agent.