Benzaldehyde, 2,5-dimethoxy-3-nitro-

Base Information

• Chemical Name: Benzaldehyde, 2,5-dimethoxy-3-nitro-
• CAS No.: 74422-90-5
• Molecular Formula: C9H9NO5
• Molecular Weight: 211.174
• DSSTox Substance ID: DTXSID10453462
• Nikkaji Number: J1.546.832G
• Wikidata: Q82274608
• Mol file: 74422-90-5.mol

Synonyms:2,5-dimethoxy-3-nitrobenzaldehyde;Benzaldehyde, 2,5-dimethoxy-3-nitro-;74422-90-5;2,5-dimethoxy-3-nitro-benzaldehyde;SCHEMBL17113788;DTXSID10453462

Chemical Property of Benzaldehyde, 2,5-dimethoxy-3-nitro-

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 211.04807239
• Heavy Atom Count: 15
• Complexity: 239

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C(=C1)[N+](=O)[O-])OC)C=O

Technology Process of Benzaldehyde, 2,5-dimethoxy-3-nitro-

There total 9 articles about Benzaldehyde, 2,5-dimethoxy-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-nitro-5-methoxysalicylaldehyde (34549-69-4) + dimethyl sulfate (77-78-1) → 2,5-dimethoxy-3-nitrobenzaldehyde (74422-90-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1039/P19900000047

Reference yield: 91.0%

3-nitro-5-methoxysalicylaldehyde (34549-69-4) + methyl iodide (74-88-4) → 2,5-dimethoxy-3-nitrobenzaldehyde (74422-90-5)

Guidance literature:

With silver(l) oxide; In chloroform; for 1.5h; Heating;

Reference yield: 66.0%

2,5-dimethoxybenzaldehyde (93-02-7) → 2,5-dimethoxy-3-nitrobenzaldehyde (74422-90-5) + 3,6-dimethoxy-2-nitrobenzaldehyde (1206-55-9)

Guidance literature:

With nitric acid; Ambient temperature;

DOI:10.1021/jm00158a002

upstream raw materials:

2,5-dimethoxybenzaldehyde

3-nitro-5-methoxysalicylaldehyde

methyl iodide

dimethyl sulfate

Downstream raw materials:

2,5-dimethoxy-3,β-dinitrostyrene

(2S,5S,6R)-(E)-methyl 6-(2,5-dimethoxy-3-nitrophenyl)-2,6-dimethoxy-5-methylhex-3-enoate

(4R,5S)-3-<(2R,3R)-3-(2,5-Dimethoxy-3-nitrophenyl)-3-hydroxy-2-methylpropanoyl>-4-methyl-5-phenyl-2-oxazolidinone

(4R,5S)-3-[(2R,3S)-3-(2,5-Dimethoxy-3-nitro-phenyl)-3-hydroxy-2-methyl-propionyl]-4-methyl-5-phenyl-oxazolidin-2-one