2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Base Information

Chemical Name:2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde
CAS No.:74427-40-0
Molecular Formula:C11H13NO2
Molecular Weight:191.23
Hs Code.:
European Community (EC) Number:817-776-9
DSSTox Substance ID:DTXSID50507852
Nikkaji Number:J2.928.671J
Wikidata:Q82364359

Synonyms:2-hydroxy-4-(pyrrolidin-1-yl)benzaldehyde;74427-40-0;2-hydroxy-4-pyrrolidin-1-ylbenzaldehyde;Benzaldehyde, 2-hydroxy-4-(1-pyrrolidinyl)-;SCHEMBL7039585;DTXSID50507852;2-hydroxy-4-pyrrolidin-1-yl-benzaldehyde;EN300-1588703;Z1511754389

Suppliers and Price of 2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

A2B
2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde 95%
1g
$ 916.00

Total 1 raw suppliers

Chemical Property of 2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Chemical Property:

PSA：40.54000
LogP:1.86990
XLogP3:2.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:191.094628657
Heavy Atom Count:14
Complexity:202

Purity/Quality:: 2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCN(C1)C2=CC(=C(C=C2)C=O)O

Technology Process of 2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

There total 9 articles about 2-Hydroxy-4-(pyrrolidin-1-yl)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.1%

: 110-52-1
1,4-dibromo-butane

: 591-27-5
m-Hydroxyaniline

: 74427-40-0
2-hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Guidance literature:: 1,4-dibromo-butane; m-Hydroxyaniline; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 24.5h; Cooling with ice;

Reference yield: 56.0%

: 25912-16-7
3-(1-pyrrolidinyl)phenol

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 74427-40-0
2-hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Guidance literature:: N,N-dimethyl-formamide; With trichlorophosphate; at 0 ℃; for 0.5h; Inert atmosphere;

3-(1-pyrrolidinyl)phenol; at 0 - 20 ℃; Inert atmosphere;

With water; Inert atmosphere;
DOI:10.1039/c0cc04113k

Reference yield:

: 32040-07-6
1-(3-methoxyphenyl)pyrrolidine

: 74427-40-0
2-hydroxy-4-(pyrrolidin-1-yl)benzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / BBr₃ / CH₂Cl₂ / 24 h

2: 1.) sodium hydride / 1.) diethyl ether, DMF, 15 min, 2.) RT, 1.5 h

3: 1.) sec-BuLi, TMEDA / 1.) cyclohexane, THF, -78 deg C, 1 h, 2.) a) -78 deg C, 4 h, b) from -78 deg C to RT, 2 h, c) RT, 0.5 h

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; boron tribromide; sodium hydride; In dichloromethane;
DOI:10.1021/jo00215a020