2-Vinyl-4,5-diphenyloxazole

Base Information

• Chemical Name: 2-Vinyl-4,5-diphenyloxazole
• CAS No.: 7449-60-7
• Molecular Formula: C17H13NO
• Molecular Weight: 247.296
• DSSTox Substance ID: DTXSID00447335
• Nikkaji Number: J1.009.069E
• Wikidata: Q82266196
• Mol file: 7449-60-7.mol

Synonyms:2-vinyl-4,5-diphenyloxazole;7449-60-7;SCHEMBL7486524;DTXSID00447335;KXFIYFSPUZSIFV-UHFFFAOYSA-N

Chemical Property of 2-Vinyl-4,5-diphenyloxazole

Chemical Property:

• XLogP3: 5.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 247.099714038
• Heavy Atom Count: 19
• Complexity: 292

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C=CC1=NC(=C(O1)C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-Vinyl-4,5-diphenyloxazole

There total 14 articles about 2-Vinyl-4,5-diphenyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

C21H18O5S + acrylonitrile (107-13-1,25014-41-9) → 4,5-diphenyl-2-vinyloxazole (7449-60-7)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 23 - 80 ℃; Inert atmosphere;

DOI:10.1055/s-0029-1218682

Reference yield: 81.0%

2-hydroxy-2-phenylacetophenone (119-53-9,579-44-2) + acrylonitrile (107-13-1,25014-41-9) → 4,5-diphenyl-2-vinyloxazole (7449-60-7)

Guidance literature:

With trifluoromethylsulfonic anhydride; sulfuric acid; at 0 - 20 ℃; for 1.16667h; Reagent/catalyst; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2017.03.046

Reference yield: 56.0%

benzil (134-81-6) + 1-amino-2-propene (107-11-9,30551-89-4) → 4,5-diphenyl-2-vinyloxazole (7449-60-7)

Guidance literature:

With copper(l) iodide; In N,N-dimethyl acetamide; at 20 ℃; Molecular sieve;

DOI:10.1039/c3ob40657a

upstream raw materials:

2-(2-bromoethyl)-4,5-diphenyl-1,3-oxazole

4,5-diphenyl-2-(5-hexenyl)oxazole

2-oxo-1,2-diphenylethyl acrylate

2-methyl-4,5-diphenyloxazole

Downstream raw materials:

2-ethyl-4,5-diphenyloxazole

2-((1S)-1,2-dihydroxyethyl)-4,5-diphenyloxazole

Refernces

• 1、 Forgács, Viktória,Németh, Enik?,Gyuricza, Barbara,Kis, Adrienn,Szabó, Judit P.,Mikecz, Pál,Mátyus, Péter,Helyes, Zsuzsanna,Horváth, ádám István,Kálai, Tamás,Trencsényi, Gy?rgy,Fekete, Anikó,Szikra, Dezs?. "Radiosynthesis and Preclinical Investigation of 11C-Labelled 3-(4,5-Diphenyl-1,3-oxazol-2-yl)propanal Oxime ([11C]SZV 1287)". . p. 2470 - 2476. Retrieved 2020/10/28.
• 2、 Hu, Ping,Wang, Qiang,Yan, Yizhe,Zhang, Shuai,Zhang, Baiqun,Wang, Zhiyong. "CuI-catalyzed and air promoted oxidative cyclization for one-pot synthesis of polyarylated oxazoles". supporting information. p. 4304 - 4307. Retrieved 2013/08/23.