3-(4-(Methoxymethoxy)phenyl)propan-1-ol

Base Information

• Chemical Name: 3-(4-(Methoxymethoxy)phenyl)propan-1-ol
• CAS No.: 74882-15-8
• Molecular Formula: C11H16O3
• Molecular Weight: 196.246
• Hs Code.: 2909499000
• DSSTox Substance ID: DTXSID70439227
• Nikkaji Number: J2.759.828E
• Wikidata: Q82255142
• Mol file: 74882-15-8.mol

Synonyms:3-(4-(methoxymethoxy)phenyl)propan-1-ol;74882-15-8;3-[4-(methoxymethoxy)phenyl]propan-1-ol;SCHEMBL5672568;DTXSID70439227;SB84667;3-[4-(methoxymethoxy)phenyl]-1-propanol;J-510636

Chemical Property of 3-(4-(Methoxymethoxy)phenyl)propan-1-ol

Chemical Property:

• PSA: 38.69000
• LogP: 1.59420
• Storage Temp.: 2-8°C
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 196.109944368
• Heavy Atom Count: 14
• Complexity: 131

Purity/Quality:

≥95% ^*data from raw suppliers

3-(4-(Methoxymethoxy)phenyl)propan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COCOC1=CC=C(C=C1)CCCO

Technology Process of 3-(4-(Methoxymethoxy)phenyl)propan-1-ol

There total 10 articles about 3-(4-(Methoxymethoxy)phenyl)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

methyl 3-<4-<(methoxymethylene)oxy>phenyl>-1-propanoate (155997-94-7) → 3-(4-methoxymethoxyphenyl)propyl alcohol (74882-15-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.1039/d0ra03674a

Reference yield: 85.0%

3-(4-(Methoxymethoxy)phenyl)propyl methoxymethyl ether → 3-(4-methoxymethoxyphenyl)propyl alcohol (74882-15-8)

Guidance literature:

3-(4-(Methoxymethoxy)phenyl)propyl methoxymethyl ether; With [2,2]bipyridinyl; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;

With water; In diethyl ether; dichloromethane; at 20 ℃; for 1h; chemoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2011.02.048

Reference yield: 59.0%

3-(4-hydroxyphenyl)propan-1-ol (10210-17-0) + chloromethyl methyl ether (107-30-2) → 3-(4-methoxymethoxyphenyl)propyl alcohol (74882-15-8)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; for 2h; Ambient temperature;

DOI:10.1021/jo971732l

upstream raw materials:

3-<4-(methoxymethoxy)phenyl>propionic acid

3-(4-hydroxyphenyl)propan-1-ol

chloromethyl methyl ether

methyl 3-<4-<(methoxymethylene)oxy>phenyl>-1-propanoate

Downstream raw materials:

1-Methoxymethoxy-4-(4-methyl-pent-3-enyl)-benzene

3-(4-methoxymethoxyphenyl)propylamine

Refernces

• 1、 -. "Method for synthesizing 1, 7-2-(4-hydroxy phenyl)-heptane-1, 4-diene-3-ketone". Paragraph 0043; 0049-0050; 0065-0066. . Retrieved 2018/04/03.
• 2、 Fujioka, Hiromichi,Kubo, Ozora,Senami, Kento,Minamitsuji, Yutaka,Maegawa, Tomohiro. "Remarkable effect of 2,2′-bipyridyl: Mild and highly chemoselective deprotection of methoxymethyl (MOM) ethers in combination with TMSOTf (TESOTf)-2,2′-bipyridyl". supporting information; experimental part. p. 4429 - 4431. Retrieved 2009/12/29.