Chemical Property of N-hexanoylsphingosine
Chemical Property:
- Vapor Pressure:1.34E-15mmHg at 25°C
- Melting Point:76-77℃
- Refractive Index:1.6000 (estimate)
- Boiling Point:574.7°C at 760 mmHg
- PKA:13.53±0.20(Predicted)
- Flash Point:301.4°C
- PSA：69.56000
- Density:0.946g/cm3
- LogP:6.05290
- Storage Temp.:−20°C
- Solubility.:Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml.
- XLogP3:7.5
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:20
- Exact Mass:397.35559436
- Heavy Atom Count:28
- Complexity:371
- Purity/Quality:
-
99% *data from raw suppliers
C6 Ceramide *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CCCCCCCCCCCCCC=CC(C(CO)NC(=O)CCCCC)O
- Isomeric SMILES:CCCCCCCCCCCCC/C=C/[C@H]([C@H](CO)NC(=O)CCCCC)O
-
Description
C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth.
-
Uses
A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway. C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.
