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142-61-0 Usage


Hexanoyl chloride, also known as butyric acid chloride or caproic acid chloride, is a chemical compound belonging to the class of acyl chlorides. It is a clear colorless to pale yellow liquid with a pungent odor. Hexanoyl chloride is an important chemical intermediate used in various industries due to its versatile reactivity and functional group.


1. Chemical Intermediate:
Hexanoyl chloride is used as a chemical intermediate for the synthesis of various organic compounds and materials. Its reactivity allows it to be a key component in the production of a wide range of chemicals.
2. Pharmaceutical Industry:
In the pharmaceutical industry, hexanoyl chloride is used as a reagent for the synthesis of various drugs and drug candidates. Its ability to form amide bonds with other molecules makes it a valuable tool in the development of new pharmaceuticals.
3. Organic Synthesis Material:
Hexanoyl chloride is also used as a material in organic synthesis, where it can be employed to introduce the hexanoyl group into a molecule. This can be useful for creating new compounds with specific properties or functions.
4. Crystal Liquid:
Hexanoyl chloride has been used as a crystal liquid, which is a substance that can be used to grow crystals for various applications, such as in the study of crystal structures or in the development of new materials.
5. Synthesis of Specific Compounds:
Hexanoyl chloride has been specifically used in the synthesis of (±)-7-butyl-6,8-dihydroxy-3-pentyl-3,4-dihydroisochromen-1-one and 14-methyl-1-octadecene. These compounds have potential applications in various fields, such as pharmaceuticals or materials science.



Check Digit Verification of cas no

The CAS Registry Mumber 142-61-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 142-61:
40 % 10 = 0
So 142-61-0 is a valid CAS Registry Number.

142-61-0 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • Alfa Aesar

  • (B23027)  Hexanoyl chloride, 98%   

  • 142-61-0

  • 100g

  • 226.0CNY

  • Detail
  • Alfa Aesar

  • (B23027)  Hexanoyl chloride, 98%   

  • 142-61-0

  • 500g

  • 877.0CNY

  • Detail
  • Aldrich

  • (294659)  Hexanoylchloride  ≥99%

  • 142-61-0

  • 294659-25ML

  • 659.88CNY

  • Detail
  • Aldrich

  • (294659)  Hexanoylchloride  ≥99%

  • 142-61-0

  • 294659-100ML

  • 2,012.40CNY

  • Detail
  • Aldrich

  • (156957)  Hexanoylchloride  97%

  • 142-61-0

  • 156957-25ML

  • 343.98CNY

  • Detail
  • Aldrich

  • (156957)  Hexanoylchloride  97%

  • 142-61-0

  • 156957-100ML

  • 455.13CNY

  • Detail
  • Aldrich

  • (156957)  Hexanoylchloride  97%

  • 142-61-0

  • 156957-500ML

  • 1,558.44CNY

  • Detail
  • Sigma-Aldrich

  • (21590)  Hexanoylchloride  purum, ≥98.0% (GC)

  • 142-61-0

  • 21590-100ML

  • 739.44CNY

  • Detail
  • Sigma-Aldrich

  • (21590)  Hexanoylchloride  purum, ≥98.0% (GC)

  • 142-61-0

  • 21590-500ML

  • 3,162.51CNY

  • Detail



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017


1.1 GHS Product identifier

Product name Hexanoyl chloride

1.2 Other means of identification

Product number -
Other names caproyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:142-61-0 SDS

142-61-0Relevant articles and documents

Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media

Kumar, Vikas,Bharate, Sonali S.,Vishwakarma, Ram A.

, p. 203 - 211 (2016)

Rohitukine is a medicinally important natural product which has inspired the discovery of two anticancer clinical candidates. Rohitukine is highly hydrophilic in nature which hampers its oral bioavailability. Thus, herein our objective was to improve the drug-like properties of rohitukine via prodrug-strategy. Various ester prodrugs were synthesized and studied for solubility, lipophilicity, chemical stability and enzymatic hydrolysis in plasma/esterase. All prodrugs displayed lower aqueous solubility and improved lipophilicity compared with rohitukine, which was in accordance with the criteria of compounds in drug-discovery. The stability of synthesized prodrugs was evaluated in buffers at different pH, SGF, SIF, rat plasma and in esterase enzyme. The rate of hydrolysis in all incubation media was dependent primarily on the acyl promoieties. Hexanoyl ester prodrug of rohitukine, 3d, was stable under chemical conditions; however it was completely hydrolyzed to rohitukine, in plasma and in esterase in 4?h. Hexanoate ester 3d appeared to be the most promising prodrug as it remained intact at gastric/intestinal pH and was completely transformed to the parent compound in plasma as desired for an ideal prodrug. The data presented herein, will help in designing prodrugs with desired physicochemical properties in future in structurally similar chemotypes.

Enantioselective total synthesis of decytospolide A and decytospolide B using an Achmatowicz reaction

Ghosh, Arun K.,Simpson, Hannah M.,Veitschegger, Anne M.

, p. 5979 - 5986 (2018)

Enantioselective syntheses of decytospolide A and decytospolide B are described here. The current synthesis highlights an Achmatowicz rearrangement of an optically active furanyl alcohol followed by reduction of the resulting dihydropyranone hemiacetal with BF3·OEt2 and Et3SiH to provide the saturated tetrahydropyranyl alcohol directly. This reduction was investigated with a variety of other Lewis acids. The synthesis also features Noyori asymmetric transfer hydrogenation and Friedel-Crafts acylation. Overall, the synthesis provides ready access to the natural products and may be useful in the preparation of bioactive derivatives.


Bally et al.

, p. 63,64,67,68 (1975)




, p. 329,332 (1942)


PCl3-mediated transesterification and aminolysis of tert-butyl esters via acid chloride formation

Wu, Xiaofang,Zhou, Lei,Li, Fangshao,Xiao, Jing

, p. 491 - 497 (2021/01/20)

A PCl3-mediated conversion of tert-butyl esters into esters and amides in one-pot under air is developed. This novel protocol is highlighted by the synthesis of skeletons of bioactive molecules and gram-scale reactions. Mechanistic studies revealed that this transformation involves the formation of an acid chloride in situ, which is followed by reactions with alcohols or amines to afford the desired products.

Benzimidazole tethered thioureas as a new entry to elastase inhibition and free radical scavenging: Synthesis, molecular docking, and enzyme inhibitory kinetics

Abbas, Qamar,Ashraf, Saba,Channar, Pervaiz Ali,Hassan, Abbas,Hassan, Mubashar,Rafique, Hummera,Raza, Hussain,Rind, Mahboob Ali,Saeed, Aamer,Seo, Sung-Yum,Ujan, Rabail,Ul-Hamid, Anwar

, (2021/07/02)

The porcine pancreatic elastase inhibition and free-radical scavenging play a crucial role in age progression. All the series of 10 newly synthesized benzimidazole thioureas (4a-j) were assessed for elastase inhibition and radical scavenging activity to identify the suitable anti-aging ingredient for cosmetics products. The compounds 4e, 4f, 4g, and 4h showed inhibition better than the standard, while compound 4f showed the most significant elastase inhibition with the IC50 value of 1.318 ± 0.025 μM compared with oleanic acid IC50 13.451 ± 0.014 used ±1.989 and 41.563 ± 0.824, respectively, as standard. Molecular docking studies were performed and the compound 4f showed binding energy of 7.2 kcal/mol. Kinetics studies revealed inhibition of the pancreatic elastase in a competitive manner. The relative binding energy and structure activity relationship (SAR) identified compound 4f as an effective inhibitor of porcine pancreatic elastase. Compounds 4e and 4i showed remarkable free-radical scavenging activity with SC50 values of 26.421.

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