4,6-Dimethyl-2-phenylpyrimidin-5-ol

Base Information

• Chemical Name: 4,6-Dimethyl-2-phenylpyrimidin-5-ol
• CAS No.: 75078-30-7
• Molecular Formula: C12H12N2O
• Molecular Weight: 200.24
• DSSTox Substance ID: DTXSID40503787
• Wikidata: Q82357830
• Mol file: 75078-30-7.mol

Synonyms:4,6-Dimethyl-2-phenylpyrimidin-5-ol;75078-30-7;2-phenyl-4,6-dimethyl-5-hydroxypyrimidine;SCHEMBL13199712;DTXSID40503787

Chemical Property of 4,6-Dimethyl-2-phenylpyrimidin-5-ol

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 200.094963011
• Heavy Atom Count: 15
• Complexity: 192

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC(=N1)C2=CC=CC=C2)C)O

Technology Process of 4,6-Dimethyl-2-phenylpyrimidin-5-ol

There total 2 articles about 4,6-Dimethyl-2-phenylpyrimidin-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

benzamidine monohydrochloride (1670-14-0) + 2-oxopropanal (78-98-8) → 2-phenyl-4,6-dimethyl-5-hydroxypyrimidine (75078-30-7)

Guidance literature:

benzamidine monohydrochloride; 2-oxopropanal; In water; at 50 ℃; for 24h; Inert atmosphere;

With sodium hydroxide; In water; at 50 ℃; for 5h;

DOI:10.1016/j.ejmech.2011.02.037

Reference yield:

→ 2-phenyl-4,6-dimethyl-5-hydroxypyrimidine (75078-30-7)

Guidance literature:

4-Methyl-5-acetyl-2-phenyl-oxazol, konz. wss. NH3-Lsg., 180grad, im Rohr;

Reference yield: 68.0%

2-phenyl-4,6-dimethyl-5-hydroxypyrimidine (75078-30-7) → 4,6-Dimethyl-1-oxy-2-phenyl-pyrimidin-5-ol (88070-46-6)

Guidance literature:

With 4-nitroperbenzoic acid; In acetone; at 25 - 40 ℃;

DOI:10.1007/BF00506890

upstream raw materials:

benzamidine monohydrochloride

2-oxopropanal

Downstream raw materials:

4-Methyl-6-(2-morpholin-4-yl-ethyl)-2-phenyl-pyrimidin-5-ol

4-[(E)-2-(4-Dimethylamino-phenyl)-vinyl]-6-methyl-2-phenyl-pyrimidin-5-ol

4,6-Bis-[(E)-2-(4-dimethylamino-phenyl)-vinyl]-2-phenyl-pyrimidin-5-ol

4,6-Dimethyl-1-oxy-2-phenyl-pyrimidin-5-ol