5-Hepten-2-one, 6-(4-methylphenyl)-

Base Information

• Chemical Name: 5-Hepten-2-one, 6-(4-methylphenyl)-
• CAS No.: 75207-32-8
• Molecular Formula: C14H18O
• Molecular Weight: 202.296
• Mol file: 75207-32-8.mol

Synonyms:

Chemical Property of 5-Hepten-2-one, 6-(4-methylphenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Hepten-2-one, 6-(4-methylphenyl)-

There total 12 articles about 5-Hepten-2-one, 6-(4-methylphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.7%

6,6-(ethylenedithio)-2-p-tolylhept-2-ene (75207-31-7) → 2-p-tolylhept-2-en-6-one (75207-32-8)

Guidance literature:

With methyl iodide; In water; acetone; for 5h; Heating;

Reference yield:

2-methylfuran (534-22-5) → 2-p-tolylhept-2-en-6-one (75207-32-8)

Guidance literature:

Multi-step reaction with 8 steps

1: 1.) n-butyl-lithium / 1.) ether, 4 h, -15 deg C, 2.) 2 h, -15 deg C

2: 69.3 percent / glacial acetic acid, 20percent H₂SO₄ / H₂O / 2 h / 120 °C

3: 82.3 percent / boron trifluoride etherate / CH₂Cl₂ / 2 h / Ambient temperature

4: 1.) sodium hydride / 1,2-dimethoxy-ethane / 1.) 0.5 h, 70 deg, 2.) 1 h, reflux

5: 79.5 percent / sodium borohydride / methanol / 1 h / Ambient temperature

6: 44.3 percent / pyridine / 8 h / Ambient temperature

7: 33.6 percent / lithium bromide / dimethylformamide / 5 h / 80 °C

8: 78.7 percent / methyl iodide / H₂O; acetone / 5 h / Heating

With sodium tetrahydroborate; n-butyllithium; sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; acetic acid; lithium bromide; methyl iodide; In pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

2-Methyl-5-<(4-methylphenyl)methyl>furan (70855-12-8) → 2-p-tolylhept-2-en-6-one (75207-32-8)

Guidance literature:

Multi-step reaction with 7 steps

1: 69.3 percent / glacial acetic acid, 20percent H₂SO₄ / H₂O / 2 h / 120 °C

2: 82.3 percent / boron trifluoride etherate / CH₂Cl₂ / 2 h / Ambient temperature

3: 1.) sodium hydride / 1,2-dimethoxy-ethane / 1.) 0.5 h, 70 deg, 2.) 1 h, reflux

4: 79.5 percent / sodium borohydride / methanol / 1 h / Ambient temperature

5: 44.3 percent / pyridine / 8 h / Ambient temperature

6: 33.6 percent / lithium bromide / dimethylformamide / 5 h / 80 °C

7: 78.7 percent / methyl iodide / H₂O; acetone / 5 h / Heating

With sodium tetrahydroborate; sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; acetic acid; lithium bromide; methyl iodide; In pyridine; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

2-(p-tolyl)but-3-en-2-ol

ethyl acetoacetate

6,6-(ethylenedithio)-2-p-tolylhept-2-ene

2-methylfuran

Downstream raw materials:

3,4'-dimethylbiphenyl

(+/-)-2-p-Tolyl-hepten-⁽²⁾-ol-⁽⁶⁾

6-(4-methylphenyl)-2-heptanone

biphenyl-3,4′-dicarboxylic acid