Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester

Base Information

Chemical Name:Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester
CAS No.:75266-48-7
Molecular Formula:C11H18O2
Molecular Weight:182.263
Hs Code.:
DSSTox Substance ID:DTXSID70449588
Nikkaji Number:J1.023.409C

Synonyms:75266-48-7;Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester;DTXSID70449588;AKOS015906922;methyl 1-cyclopropylcyclohexanecarboxylate;1-Cyclopropylcyclohexanecarboxylic acid methyl ester;1-cyclopropyl-cyclohexane-1-carboxylic acid methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:182.130679813
Heavy Atom Count:13
Complexity:200

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1(CCCCC1)C2CC2

Technology Process of Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester

There total 3 articles about Cyclohexanecarboxylic acid, 1-cyclopropyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 591-87-7
Allyl acetate

: 40195-26-4
1-methoxy-1-trimethylsilyloxymethylenecyclohexane

: 67838-02-2
methyl 1-allylcyclohexane-1-carboxylate

: 75266-48-7
1-Cyclopropyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With <(η³-C3H5)Pd(MePPH)>⁺BF4^-; sodium acetate; In dimethyl sulfoxide; Ambient temperature;
DOI:10.1021/ja982269c

Reference yield:

: methyl cyclohexanecarboxylate

: 75266-48-7
1-Cyclopropyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; triethylamine; diisopropylamine; Yield given. Multistep reaction; 1) THF, -78 deg C , 10 min., 10min. at 0 deg C; 2) THF, -78 deg C, 20 min.;
DOI:10.1021/jo01313a034

Reference yield:

: 4630-82-4
methyl cyclohexylcarboxylate

: 12012-95-2
?-allylpalladium chloride dimer

: 75266-48-7
1-Cyclopropyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; carbon monoxide; lithium diisopropyl amide; Yield given. Multistep reaction; 1a) THF, hexane, -78 deg -C, 10 min, 1b) 0 deg C, 10 min, 2a) THF, -60 to 25 deg C, 2b) 25 deg C, 1h;