1-Iodomethyl-1,3-dicarbomethoxycyclohexane

Base Information

Chemical Name:1-Iodomethyl-1,3-dicarbomethoxycyclohexane
CAS No.:75328-53-9
Molecular Formula:C11H17IO4
Molecular Weight:340.158
Hs Code.:
DSSTox Substance ID:DTXSID401200445

Synonyms:75328-53-9;SCHEMBL2876067;HCZDVILANWUSFD-UHFFFAOYSA-N;DTXSID401200445;1-iodomethyl-1,3-dicarbomethoxycyclohexane;1,3-Dimethyl 1-(iodomethyl)-1,3-cyclohexanedicarboxylate

Suppliers and Price of 1-Iodomethyl-1,3-dicarbomethoxycyclohexane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Iodomethyl-1,3-dicarbomethoxycyclohexane

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:340.01716
Heavy Atom Count:16
Complexity:279

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CCCC(C1)(CI)C(=O)OC

Technology Process of 1-Iodomethyl-1,3-dicarbomethoxycyclohexane

There total 3 articles about 1-Iodomethyl-1,3-dicarbomethoxycyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 75-11-6
diiodomethane

: 62638-06-6
dimethyl cyclohexane-1,3-dicarboxylate

: 75328-53-9
1-(Iodomethyl)-1,3-bis(carbomethoxy)cyclohexane

Guidance literature:: dimethyl cyclohexane-1,3-dicarboxylate; With 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium diisopropyl amide; In tetrahydrofuran; hexane; at -67 - -60 ℃; for 1h;

diiodomethane; In tetrahydrofuran; hexane; at -67 - 20 ℃; for 2h;

Reference yield:

: 121-91-5
isophthalic acid

: 75328-53-9
1-(Iodomethyl)-1,3-bis(carbomethoxy)cyclohexane

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / p-toluenesulfonic acid

2: 85 percent / H₂ / 5percent rhodium on alumina / 2585.7 Torr

3: 66 percent / lithium diisopropylamide / 1.) -78 deg C, 1 h, 2.) 25 deg C

With hydrogen; toluene-4-sulfonic acid; lithium diisopropyl amide; Rh/Al₂O₃;
DOI:10.1021/ja00542a040

Reference yield:

: 1459-93-4
dimethyl Isophthalate

: 75328-53-9
1-(Iodomethyl)-1,3-bis(carbomethoxy)cyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / H₂ / 5percent rhodium on alumina / 2585.7 Torr

2: 66 percent / lithium diisopropylamide / 1.) -78 deg C, 1 h, 2.) 25 deg C

With hydrogen; lithium diisopropyl amide; Rh/Al₂O₃;
DOI:10.1021/ja00542a040