Benzenemethanamine, N-[cis-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-N-(phenylmeth yl)-

Base Information

Chemical Name:Benzenemethanamine, N-[cis-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-N-(phenylmeth yl)-
CAS No.:755039-88-4
Molecular Formula:C28H39N3
Molecular Weight:417.638
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzenemethanamine, N-[cis-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-N-(phenylmeth yl)-

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Technology Process of Benzenemethanamine, N-[cis-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-N-(phenylmeth yl)-

There total 9 articles about Benzenemethanamine, N-[cis-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-N-(phenylmeth yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 57184-25-5
1-cyclopropylmethylpiperazine

: 149506-79-6
4-(dibenzylamino)cyclohexanone

: 755039-89-5
(trans)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

: 755039-88-4
(cis)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

Guidance literature:: With sodium tris(acetoxy)borohydride; In dichloromethane; at 20 ℃; for 12h;

Reference yield: 34.1%

: 373608-42-5
1-(cyclopropylmethyl)piperazine dihydrochloride

: 149506-79-6
4-(dibenzylamino)cyclohexanone

: 755039-88-4
(cis)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

Guidance literature:: 1-(cyclopropylmethyl)piperazine dihydrochloride; 4-(dibenzylamino)cyclohexanone; With sodium acetate; sodium tris(acetoxy)borohydride; In acetonitrile; at 20 - 30 ℃; for 12h; pH=6 - 7; Inert atmosphere;

With water; sodium carbonate; In acetonitrile; pH=8;

Reference yield:

: 149506-81-0
trans-4-(dibenzylamino)cyclohexanol

: 755039-88-4
(cis)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Jones reagent / acetone / 0.58 h / 20 - 30 °C / Cooling with ice; Inert atmosphere

2.1: sodium acetate; sodium tris(acetoxy)borohydride / acetonitrile / 12 h / 20 - 30 °C / pH 6 - 7 / Inert atmosphere

2.2: pH 8

With Jones reagent; sodium acetate; sodium tris(acetoxy)borohydride; In acetone; acetonitrile;