7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

Base Information

Chemical Name:7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide
CAS No.:1280665-14-6
Molecular Formula:C₃₉H₅₆N₈O₃
Molecular Weight:684.925
Hs Code.:

7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

Synonyms:7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

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Chemical Property of 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

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Technology Process of 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

There total 15 articles about 7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.9%

: 755039-90-8
(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

: 1280665-93-1
7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-2,2-dimethyl-3H-benzofuran-4-carboxylic acid

: 1280665-14-6
7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 - 30 ℃; for 3h; Inert atmosphere;

Reference yield:

: 755039-88-4
(cis)-N,N-dibenzyl-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexanamine

: 1280665-14-6
7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; acetic acid / palladium 10% on activated carbon / dichloromethane; methanol / 12 h / 20 - 30 °C / 2280.15 Torr / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 - 30 °C / Inert atmosphere

With hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

: 619-14-7
3-hydroxy-4-nitro-benzoic acid

: 1280665-14-6
7-[[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-7H-pteridin-2-yl]amino]-N-[(cis)-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-2,2-dimethyl-3H-benzofuran-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: thionyl chloride / 2 h / 0 °C / Reflux; Inert atmosphere

2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0.17 h / Cooling with ice; Inert atmosphere

2.2: 12 h / 20 - 30 °C / Inert atmosphere

3.1: 3 h / 190 °C / Inert atmosphere

4.1: trifluorormethanesulfonic acid / 1,1-dichloroethane / 2 h / Inert atmosphere

5.1: acetic acid; iron / 12 h / 20 - 30 °C / Inert atmosphere

5.2: pH 7 - 8

6.1: toluene-4-sulfonic acid / Methyl isobutyl carbinol / 2 h / Reflux; Inert atmosphere

7.1: water; lithium hydroxide / methanol / 12 h / 50 °C / Inert atmosphere

7.2: pH 2 - 3

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 - 30 °C / Inert atmosphere

With thionyl chloride; water; iron; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; toluene-4-sulfonic acid; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; trifluorormethanesulfonic acid; In tetrahydrofuran; methanol; Methyl isobutyl carbinol; 1,1-dichloroethane; dichloromethane;