Ethanethioic acid, S-[(1R,2S)-3-methyl-1-phenyl-2-(1-pyrrolidinyl)butyl] ester

Base Information

Chemical Name:Ethanethioic acid, S-[(1R,2S)-3-methyl-1-phenyl-2-(1-pyrrolidinyl)butyl] ester
CAS No.:757243-39-3
Molecular Formula:C17H25NOS
Molecular Weight:291.458
Hs Code.:

Synonyms:

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Chemical Property of Ethanethioic acid, S-[(1R,2S)-3-methyl-1-phenyl-2-(1-pyrrolidinyl)butyl] ester

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Technology Process of Ethanethioic acid, S-[(1R,2S)-3-methyl-1-phenyl-2-(1-pyrrolidinyl)butyl] ester

There total 11 articles about Ethanethioic acid, S-[(1R,2S)-3-methyl-1-phenyl-2-(1-pyrrolidinyl)butyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 111060-66-3
L-dibenzylvalinal

: 757243-39-3
(S)-(1R,2S)-3-methyl-1-phenyl-2-(pyrrolidin-1-yl)butyl ethanetioate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 69 percent / tetrahydrofuran / 1 h / 0 °C

2.1: 92 percent / H₂ / Pd/C / methanol / 8 h / 20 °C / 760 Torr

3.1: K₂CO₃ / acetonitrile / 18 h / Heating

4.1: Et₃N; MsCl / CH₂Cl₂ / 1 h / 0 °C

4.2: benzene / 8 h / Heating

With hydrogen; potassium carbonate; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.tetasy.2004.08.009

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 757243-39-3
(S)-(1R,2S)-3-methyl-1-phenyl-2-(pyrrolidin-1-yl)butyl ethanetioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: NaOH

2.1: LiAlH₄

3.1: 69 percent / tetrahydrofuran / 1 h / 0 °C

4.1: 92 percent / H₂ / Pd/C / methanol / 8 h / 20 °C / 760 Torr

5.1: K₂CO₃ / acetonitrile / 18 h / Heating

6.1: Et₃N; MsCl / CH₂Cl₂ / 1 h / 0 °C

6.2: benzene / 8 h / Heating

With sodium hydroxide; lithium aluminium tetrahydride; hydrogen; potassium carbonate; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 3.1: Swern oxidation;
DOI:10.1016/j.tetasy.2004.08.009

Reference yield:

: 111060-54-9,372967-45-8
N,N-dibenzylvalinol

: 757243-39-3
(S)-(1R,2S)-3-methyl-1-phenyl-2-(pyrrolidin-1-yl)butyl ethanetioate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 69 percent / tetrahydrofuran / 1 h / 0 °C

2.1: 92 percent / H₂ / Pd/C / methanol / 8 h / 20 °C / 760 Torr

3.1: K₂CO₃ / acetonitrile / 18 h / Heating

4.1: Et₃N; MsCl / CH₂Cl₂ / 1 h / 0 °C

4.2: benzene / 8 h / Heating

With hydrogen; potassium carbonate; methanesulfonyl chloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; acetonitrile; 1.1: Swern oxidation;
DOI:10.1016/j.tetasy.2004.08.009