2,4-Dimethoxynaphthalene-1-carbaldehyde

Base Information

• Chemical Name: 2,4-Dimethoxynaphthalene-1-carbaldehyde
• CAS No.: 75965-84-3
• Molecular Formula: C₁₃H₁₂O₃
• Molecular Weight: 216.236
• DSSTox Substance ID: DTXSID20503361
• Wikidata: Q82357111
• Mol file: 75965-84-3.mol

Synonyms:75965-84-3;2,4-dimethoxy-1-naphthaldehyde;2,4-Dimethoxynaphthalene-1-carbaldehyde;2,4-Dimethoxy-naphthalene-1-carbaldehyde;1-Naphthalenecarboxaldehyde, 2,4-dimethoxy-;SCHEMBL1004872;DTXSID20503361;NNQTVZVNHYJOKQ-UHFFFAOYSA-N;MFCD30185873;AKOS022652045;AS-65877;W11784

Chemical Property of 2,4-Dimethoxynaphthalene-1-carbaldehyde

Chemical Property:

• Melting Point: 165 °C(Solv: ethanol (64-17-5))
• Boiling Point: 215-235 °C(Press: 13 Torr)
• PSA: 35.53000
• Density: 1.180±0.06 g/cm3(Predicted)
• LogP: 2.66950
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.078644241
• Heavy Atom Count: 16
• Complexity: 241

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dimethoxy-1-naphthaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C2=CC=CC=C21)C=O)OC

Technology Process of 2,4-Dimethoxynaphthalene-1-carbaldehyde

There total 8 articles about 2,4-Dimethoxynaphthalene-1-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

malonic acid (141-82-2) + 1,3-dimethoxynaphthalene (10075-61-3) → 2,4-dimethoxy-1-naphthalenecarbaldehyde (75965-84-3)

Guidance literature:

With manganese triacetate; In acetic acid; for 0.0166667h; Heating;

DOI:10.1246/bcsj.62.545

Reference yield:

1,3-dihydroxynaphthalene (132-86-5) → 2,4-dimethoxy-1-naphthalenecarbaldehyde (75965-84-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 53 percent / manganese(III) acetate / acetic acid / 0.02 h / Heating

With manganese triacetate; In acetic acid;

DOI:10.1246/bcsj.62.545

Reference yield:

1,3-dihydroxynaphthalene (132-86-5) → 2,4-dimethoxy-1-naphthalenecarbaldehyde (75965-84-3)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous KOH

2: POCl₃; toluene / anschliessendes Erwaermen mit wss.NaOH

With potassium hydroxide; toluene; trichlorophosphate;

DOI:10.1021/jo01115a024

upstream raw materials:

1,3-dimethoxynaphthalene

N,N-dimethyl-formamide

malonic acid

2,4-dihydroxy-[1]naphthaldehyde

Downstream raw materials:

nitro-2 methoxy-5 naphto<2,1-b>furanne