1,3-Dimethoxynaphthalene

Base Information

• Chemical Name: 1,3-Dimethoxynaphthalene
• CAS No.: 10075-61-3
• Molecular Formula: C12H12O2
• Molecular Weight: 188.226
• DSSTox Substance ID: DTXSID50357894
• Nikkaji Number: J1.644.059K
• Wikidata: Q82138072
• Mol file: 10075-61-3.mol

Synonyms:1,3-dimethoxynaphthalene;10075-61-3;Naphthalene, 1,3-dimethoxy-;SCHEMBL443362;AMY6592;DTXSID50357894;XAVOEDQPSYWNHI-UHFFFAOYSA-N;1,3-dimethoxynaphthalene, AldrichCPR;AKOS006274773;C13981

Chemical Property of 1,3-Dimethoxynaphthalene

Chemical Property:

• Boiling Point: 172-173 °C(Press: 12 Torr)
• PSA: 18.46000
• Density: 1.097±0.06 g/cm3(Predicted)
• LogP: 2.85700
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 188.083729621
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,3-Dimethoxynaphthalene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=CC=CC=C2C(=C1)OC

Technology Process of 1,3-Dimethoxynaphthalene

There total 10 articles about 1,3-Dimethoxynaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,3-dihydroxynaphthalene (132-86-5) + dimethyl sulfate (77-78-1) → 1,3-dimethoxynaphthalene (10075-61-3)

Guidance literature:

With potassium carbonate; In acetone;

DOI:10.1016/S0040-4039(00)77579-4

Reference yield: 85.0%

1,3-dibromonaphthalene (52358-73-3) + sodium methylate (124-41-4) → 1,3-dimethoxynaphthalene (10075-61-3)

Guidance literature:

With copper(l) iodide; In methanol; N,N-dimethyl-formamide; at 90 ℃; for 10h;

Reference yield: 85.0%

C12H14O3 (1341189-09-0) → 1,3-dimethoxynaphthalene (10075-61-3)

Guidance literature:

With indium (III) iodide; In dichloromethane; at 0 - 23 ℃; Inert atmosphere;

DOI:10.1021/ol202621g

upstream raw materials:

diazomethane

ethyl 1,3-dihydroxy-2-naphthoate

1,3-dihydroxynaphthalene

dimethyl sulfate

Downstream raw materials:

2,4-dimethoxy-1-naphthalenecarbaldehyde

1-Acetyl-4-methoxy-2-naphthol

2-Chlor-6-methoxy-4,5-benzotropon

5-Chlor-6-methoxy-2,3-benzotropon

Refernces

• 1、 Demirtas, Ibrahim,Erenler, Ramazan,Cakmak, Osman. "Synthetic route to 1,3-disubstituted naphthalene derivatives". . p. 524 - 526. Retrieved 2007/10/03.
• 2、 Coleman, Robert S.,Grant, Eugene B.. "Application of a Cu(I)-mediated biaryl cross-coupling reaction to the synthesis of oxygenated 1,1′-binaphthalenes". . p. 2225 - 2228. Retrieved 2007/10/02.