7-Methoxy-1H-pyrazolo[3,4-c]pyridine

Base Information

• Chemical Name: 7-Methoxy-1H-pyrazolo[3,4-c]pyridine
• CAS No.: 76006-10-5
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 149.152
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID00506259
• Nikkaji Number: J2.396.559C
• Wikidata: Q82361942
• Mol file: 76006-10-5.mol

Synonyms:7-Methoxy-1H-pyrazolo[3,4-c]pyridine;76006-10-5;7-Methoxy-2h-pyrazolo[3,4-c]pyridine;MFCD09265712;1H-Pyrazolo[3,4-c]pyridine,7-methoxy-;DTXSID00506259;BDA00610;AKOS016006232;SB13726;SY077260;CS-0256371;G10591

Chemical Property of 7-Methoxy-1H-pyrazolo[3,4-c]pyridine

Chemical Property:

• PSA: 50.80000
• LogP: 0.96650
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 149.058911855
• Heavy Atom Count: 11
• Complexity: 142

Purity/Quality:

97% ^*data from raw suppliers

7-Methoxy-1H-pyrazolo[3,4-c]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=NC=CC2=C1NN=C2

Technology Process of 7-Methoxy-1H-pyrazolo[3,4-c]pyridine

There total 3 articles about 7-Methoxy-1H-pyrazolo[3,4-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-methoxy-3-amino-4-methylpyridine (76005-99-7) → 7-methoxy-1H-pyrazolo<3,4-c>pyridine (76006-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 54 percent / toluene / 2 h / 100 °C

2: 1.) phosphorus pentaoxide, potassium acetate, nitrosyl chloride, 2.) sodium carbonate / 1.) acetic acid, 30 min, 2.) benzene, 2 h, reflux

With phosphorus pentaoxide; potassium acetate; sodium carbonate; nitrosylchloride; In toluene;

Reference yield:

3-Amino-2-chloro-4-methylpyridine (133627-45-9) → 7-methoxy-1H-pyrazolo<3,4-c>pyridine (76006-10-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium; copper(l) iodide / 14 h / 110 °C / Autoclave

2.1: potassium acetate; acetic anhydride / dichloromethane / 0.67 h / 0 °C

2.2: 12 h / 0 - 65 °C / Reflux

2.3: 1 h / 20 °C

With copper(l) iodide; potassium acetate; sodium; acetic anhydride; In dichloromethane;

Reference yield:

3-acetamido-2-methoxy-4-methylpyridine (76005-98-6) → 7-methoxy-1H-pyrazolo<3,4-c>pyridine (76006-10-5)

Guidance literature:

With phosphorus pentaoxide; potassium acetate; sodium carbonate; nitrosylchloride; Yield given. Multistep reaction; 1.) acetic acid, 30 min, 2.) benzene, 2 h, reflux;

upstream raw materials:

3-acetamido-2-methoxy-4-methylpyridine

2-methoxy-3-amino-4-methylpyridine

3-Amino-2-chloro-4-methylpyridine

Downstream raw materials:

1H-pyrazolo<3,4-c>pyridin-7(6H)-one

7-chloro-1H-pyrazolo<3,4-c>pyridine

7-anilino-1H-pyrazolo<3,4-c>pyridine

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