3-Amino-2-methoxy-4-picoline

Base Information

• Chemical Name: 3-Amino-2-methoxy-4-picoline
• CAS No.: 76005-99-7
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID20438109
• Wikidata: Q72438742
• Mol file: 76005-99-7.mol

Synonyms:76005-99-7;2-methoxy-4-methylpyridin-3-amine;3-Amino-2-methoxy-4-picoline;2-Methoxy-3-amino-4-picoline;3-amino-2-methoxy-4-methylpyridine;MFCD08277287;2-methoxy-4-methyl-pyridin-3-amine;SCHEMBL56189;DTXSID20438109;IEJSXJLVJOGKMB-UHFFFAOYSA-N;2-methoxy-3-amino-4-methylpyridine;3-amino-4-methyl-2-methoxy pyridine;2-Methoxy-4-methyl-pyridin-3-ylamine;AKOS013465887;SB75590;AS-33110;SY110546;3-amino-2-methoxy-4-picoline, AldrichCPR;CS-0153646;FT-0655770;EN300-1296073;A838581;J-511549

Chemical Property of 3-Amino-2-methoxy-4-picoline

Chemical Property:

• Vapor Pressure: 0.00921mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 265.3 °C at 760 mmHg
• PKA: 4.99±0.18(Predicted)
• Flash Point: 114.3 °C
• PSA: 48.14000
• Density: 1.103 g/cm³
• LogP: 1.56200
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 108

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxy-4-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=NC=C1)OC)N

Technology Process of 3-Amino-2-methoxy-4-picoline

There total 5 articles about 3-Amino-2-methoxy-4-picoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-Methoxy-4-methyl-3-pyridinecarbamic acid 1,1-dimethylethyl ester → 2-methoxy-3-amino-4-methylpyridine (76005-99-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; Ambient temperature;

DOI:10.1021/jo00111a056

Reference yield: 81.0%

2-methoxy-4-methyl-3-nitropyridine (160590-36-3) → 2-methoxy-3-amino-4-methylpyridine (76005-99-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; at 25 - 90 ℃; for 2h;

Reference yield: 78.7%

methanol (67-56-1) + 3-Amino-2-chloro-4-methylpyridine (133627-45-9) → 2-methoxy-3-amino-4-methylpyridine (76005-99-7)

Guidance literature:

With copper(l) iodide; sodium; at 110 ℃; for 14h; Autoclave;

upstream raw materials:

2-methoxy-4-methyl-3-nitropyridine

methanol

3-Amino-2-chloro-4-methylpyridine

Downstream raw materials:

3,6-Dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid (2-methoxy-4-methyl-pyridin-3-yl)-amide

7-anilino-1H-pyrazolo<3,4-c>pyridine

7-methoxy-1H-pyrazolo<3,4-c>pyridine

1H-pyrazolo<3,4-c>pyridin-7(6H)-one

Refernces

• 1、 -. "A pyrazole compound pyridine and its preparation method". Paragraph 0025; 0026; 0033. . Retrieved 2018/01/19.
• 2、 -. "PYRAZOLOPYRIDINES USEFUL IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM". Page/Page column 29. . Retrieved 2013/03/26.