His-Val

Base Information

Chemical Name:His-Val
CAS No.:76019-15-3
Molecular Formula:C₁₁H₁₈N₄O₃
Molecular Weight:254.289
Hs Code.:
European Community (EC) Number:857-890-6
DSSTox Substance ID:DTXSID701315425
Nikkaji Number:J764.221K
Wikidata:Q27144373
Metabolomics Workbench ID:78835
Mol file:76019-15-3.mol

Synonyms:H-His-Val-OH;His-Val;76019-15-3;L-histidyl-L-valine;histidylvaline;(2S)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoic acid;Histidyl-valine;Histidinylvaline;HV dipeptide;Histidinyl-Valine;H-V Dipeptide;L-His-L-Val;L-Histidinyl-L-Valine;Histidine Valine dipeptide;Histidine-Valine dipeptide;SCHEMBL8437182;CHEBI:74060;DTXSID701315425;HV;MFCD00037856;Q27144373;(2S)-2-[(2S)-2-amino-3-(1H-imidazol-5-yl)propanamido]-3-methylbutanoic acid

Suppliers and Price of His-Val

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
H-His-Val-OH
250mg
$ 394.00

Total 12 raw suppliers

Chemical Property of His-Val

Chemical Property:

Melting Point:206 - 207 °C (ethanol)
PSA：121.10000
LogP:0.59610
Storage Temp.:-15°C
XLogP3:-2.5
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:254.13789045
Heavy Atom Count:18
Complexity:309

Purity/Quality:

99% ^*data from raw suppliers

H-His-Val-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)C(C(=O)O)NC(=O)C(CC1=CN=CN1)N
Isomeric SMILES:CC(C)[C@@H](C(=O)O)NC(=O)[C@H](CC1=CN=CN1)N

Technology Process of His-Val

There total 4 articles about His-Val which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Fmoc-Val-Wang resin

: 109425-51-6
Fmoc-His(Trt)-OH

: 76019-15-3
His-Val

Guidance literature:: Fmoc-Val-Wang resin; With piperidine; In N,N-dimethyl-formamide; for 0.5h; polystyrene resin

Fmoc-His(Trt)-OH; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; polystyrene resin

With chlorotriisopropylsilane; ethane-1,2-dithiol; trifluoroacetic acid; In water; for 2h; polystyrene resin
DOI:10.1016/j.tetlet.2019.05.069

Reference yield:

: 106172-66-1,114247-59-5
N-(N^α-benzyloxycarbonyl-L-histidyl)-Ξ-valine

: 70626-51-6,76019-15-3
N-L-histidyl-Ξ-valine

Guidance literature:: With methanol; palladium; acetic acid; Hydrogenation;

Reference yield:

: 13893-45-3
valine ethyl ester

: 70626-51-6,76019-15-3
N-L-histidyl-Ξ-valine

Guidance literature:: Multi-step reaction with 2 steps

1: THF / und anschliessendes Behandeln mit wss.-methanol.NaOH

2: palladium; acetic acid; aqueous methanol / Hydrogenation

With tetrahydrofuran; methanol; palladium; acetic acid;