4-ACETOXY TAMOXIFEN

Base Information

• Chemical Name: 4-ACETOXY TAMOXIFEN
• CAS No.: 76117-69-6
• Molecular Formula: C₂₈H₃₁NO₃
• Molecular Weight: 429.559
• Mol file: 76117-69-6.mol

Synonyms:4-Acetoxy Tamoxifen;

Chemical Property of 4-ACETOXY TAMOXIFEN

Chemical Property:

• Vapor Pressure: 1.13E-11mmHg at 25°C
• PSA: 38.77000
• LogP: 5.92140

Purity/Quality:

99% ^*data from raw suppliers

4-Acetoxy Tamoxifen ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A derivative of Tamoxifen

Technology Process of 4-ACETOXY TAMOXIFEN

There total 3 articles about 4-ACETOXY TAMOXIFEN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetyl chloride (75-36-5) + 4-hydroxytamoxifen (68392-35-8,65213-48-1) → (E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenylbut-1-enyl}phenyl acetate (76117-70-9,76117-69-6) + C28H31NO3

Guidance literature:

With pyridine; for 1h; Heating / reflux;

Reference yield:

acetic anhydride (108-24-7) + Z-1-<4-(2-dimethylaminoethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene (68047-06-3,65213-48-1) → (E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenylbut-1-enyl}phenyl acetate (76117-70-9,76117-69-6)

Guidance literature:

at 20 ℃; for 24h;

DOI:10.1016/j.bcp.2006.01.004

Reference yield:

→ (E)-4-{1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenylbut-1-enyl}phenyl acetate (76117-70-9,76117-69-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 0.5h;

at 50 ℃; for 12h;

upstream raw materials:

acetic anhydride

Z-1-<4-(2-dimethylaminoethoxy)phenyl>-1-(4-hydroxyphenyl)-2-phenyl-1-butene

acetyl chloride

4-hydroxytamoxifen

Refernces

• 1、 -. "ERR MODULATORS AND USES THEREOF". Paragraph 0492; 0493; 0494. . Retrieved 2018/11/21.