1-[3-(Benzyloxy)phenyl]azetidin-2-one

Base Information

Chemical Name:1-[3-(Benzyloxy)phenyl]azetidin-2-one
CAS No.:76228-00-7
Molecular Formula:C16H15NO2
Molecular Weight:253.301
Hs Code.:
DSSTox Substance ID:DTXSID60505541
Wikidata:Q82360741

Synonyms:76228-00-7;1-[3-(Benzyloxy)phenyl]azetidin-2-one;SCHEMBL5737605;DTXSID60505541

Suppliers and Price of 1-[3-(Benzyloxy)phenyl]azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[3-(Benzyloxy)phenyl]azetidin-2-one

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:253.110278721
Heavy Atom Count:19
Complexity:312

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(C1=O)C2=CC(=CC=C2)OCC3=CC=CC=C3

Technology Process of 1-[3-(Benzyloxy)phenyl]azetidin-2-one

There total 3 articles about 1-[3-(Benzyloxy)phenyl]azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 620597-98-0
N-(3-(benzyloxy)phenyl)-3-bromopropanamide

: 76228-00-7
1-(3-benzyloxy-phenyl)-azetidin-2-one

Guidance literature:: With potassium hydroxide; tetrabutylammomium bromide; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2003.08.022

Reference yield: 40.0%

: 76227-97-9
3-(3-Benzyloxy-phenylamino)-propionic acid ethyl ester

: 76228-00-7
1-(3-benzyloxy-phenyl)-azetidin-2-one

Guidance literature:: With ethylmagnesium bromide; In tetrahydrofuran; for 14h;
DOI:10.1039/P19800002105

Reference yield:

: 1484-26-0
3-(benzyloxy)aniline

: 76228-00-7
1-(3-benzyloxy-phenyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / EDC; DMAP / CH₂Cl₂ / 0.5 h / 20 °C

2: 74 percent / KOH; tetrabutylammonium bromide / CH₂Cl₂ / 3 h / 20 °C

With dmap; potassium hydroxide; tetrabutylammomium bromide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane;
DOI:10.1016/j.bmc.2003.08.022