7-CHLORO-4-HYDROXY-3-NITROQUINOLINE

Base Information

• Chemical Name: 7-CHLORO-4-HYDROXY-3-NITROQUINOLINE
• CAS No.: 5350-50-5
• Molecular Formula: C9H5 Cl N2 O3
• Molecular Weight: 224.6006
• Hs Code.: 2933499090
• Mol file: 5350-50-5.mol

Synonyms:7-Chloro-3-nitroquinolin-4-ol;7-Chloro-4-hydroxy-3-nitroquinoline; NSC 35; NSC 4471

Chemical Property of 7-CHLORO-4-HYDROXY-3-NITROQUINOLINE

Chemical Property:

• Vapor Pressure: 4.38E-05mmHg at 25°C
• Boiling Point: 350.5°Cat760mmHg
• Flash Point: 165.8°C
• PSA: 78.94000
• Density: 1.58g/cm³
• LogP: 3.02520
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

7-Chloro-4-hydroxy-3-nitroquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-CHLORO-4-HYDROXY-3-NITROQUINOLINE

There total 4 articles about 7-CHLORO-4-HYDROXY-3-NITROQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

7-chloro-4-hydroxylquinoline (86-99-7) → 7-chloro-3-nitro-4-hydroxyquinoline (5350-50-5)

Guidance literature:

With nitric acid; propionic acid; at 125 ℃;

DOI:10.1021/acs.jmedchem.5b01374

Reference yield:

7-chloro-4-hydroxylquinoline (86-99-7) → 7-chloro-2-propylthiazolo[4,5-c]quinolin-4-amine + 7-chloro-3-nitro-4-hydroxyquinoline (5350-50-5)

Guidance literature:

With nitric acid;

Reference yield:

4,7-dichloroquinoline (86-98-6,1138471-54-1) → 7-chloro-3-nitro-4-hydroxyquinoline (5350-50-5)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 1 h / 125 °C

2: sodium hydroxide

3: nitric acid; propionic acid / 125 °C

With nitric acid; acetic acid; propionic acid; sodium hydroxide;

DOI:10.1021/acs.jmedchem.5b01374

upstream raw materials:

7-chloro-4-hydroxylquinoline

4,7-dichloroquinoline

Downstream raw materials:

4,7-dichloro-3-nitroquinoline

4,7-dichloro-3-iodoquinoline

(7-chloro-3-nitro-[4]quinolyl)-phenyl-amine

3-bromo-7-chloroquinoline

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