7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine

Base Information

• Chemical Name: 7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine
• CAS No.: 76466-48-3
• Molecular Formula: C₈H₁₃N
• Molecular Weight: 123.198
• DSSTox Substance ID: DTXSID40524891
• Wikidata: Q82392075
• Mol file: 76466-48-3.mol

Synonyms:7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine;76466-48-3;DTXSID40524891

Chemical Property of 7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine

Chemical Property:

• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 123.104799419
• Heavy Atom Count: 9
• Complexity: 158

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2CCCN2CC1

Technology Process of 7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine

There total 1 articles about 7-Methyl-2,3,5,6-tetrahydro-1H-pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

γ-(N-2-oxopyrrolidinyl)-α-methylbutyric acid (76466-47-2) → 1-methyl-Δ7(8)-dehydropyrrolizine (76466-49-4) + 1-methyl-Δ1(8)dehydropyrrolizidine (76466-48-3)

Guidance literature:

With soda lime; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

DOI:10.1021/jo00321a046

Reference yield: 83.0%

1-methyl-Δ1(8)dehydropyrrolizidine (76466-48-3) + phenyl isocyanate (103-71-9) → 4-Methyl-5-oxo-1-(N-phenylcarbamoyl)perhydroazocine (106032-24-0)

Guidance literature:

In chloroform; water;

DOI:10.3987/R-1986-08-2121

Reference yield: 64.0%

1-methyl-Δ1(8)dehydropyrrolizidine (76466-48-3) + phenyl isocyanate (103-71-9) → 2,3,5,6-tetrahydro-1-methyl-7-(N-phenyl)carbamoyl-1H-pyrrolizine (106032-26-2)

Guidance literature:

In diethyl ether;

DOI:10.3987/R-1986-08-2121

upstream raw materials:

γ-(N-2-oxopyrrolidinyl)-α-methylbutyric acid

Downstream raw materials:

2,3,5,6-tetrahydro-1-methyl-7-(N-phenyl)carbamoyl-1H-pyrrolizine

4-Methyl-5-oxo-1-(N-phenylcarbamoyl)perhydroazocine