2-(3,4-dimethoxyphenyl)butanedinitrile

Base Information

• Chemical Name: 2-(3,4-dimethoxyphenyl)butanedinitrile
• CAS No.: 6286-49-3
• Molecular Formula: C12H12N2O2
• Molecular Weight: 216.239
• Mol file: 6286-49-3.mol

Synonyms:

Chemical Property of 2-(3,4-dimethoxyphenyl)butanedinitrile

Chemical Property:

• Vapor Pressure: 6.1E-07mmHg at 25°C
• Boiling Point: 410.3°Cat760mmHg
• Flash Point: 170.7°C
• Density: 1.133g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3,4-dimethoxyphenyl)butanedinitrile

There total 4 articles about 2-(3,4-dimethoxyphenyl)butanedinitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate (2286-55-7) + sodium cyanide (143-33-9,25596-52-5) → 2-(3,4-dimethoxyphenyl)succinonitrile (6286-49-3)

Guidance literature:

In ethanol; chloroform; water; for 15h; Heating;

DOI:10.1002/jps.2600731125

Reference yield: 41.0%

sodium cyanide (773837-37-9) + dimethyl 2-(3,4-dimethoxyphenyl)cyclopropane-1,1-dicarboxylate → 2-(3,4-dimethoxyphenyl)succinonitrile (6286-49-3)

Guidance literature:

With nitromethane; In dimethyl sulfoxide; at 120 ℃; for 1h; Reagent/catalyst; Solvent; Temperature; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.joc.9b03098

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → 2-(3,4-dimethoxyphenyl)succinonitrile (6286-49-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / piperidine / toluene / 110 °C

2: 84 percent / CHCl₃; ethanol; H₂O / 15 h / Heating

With piperidine; In ethanol; chloroform; water; toluene;

DOI:10.1002/jps.2600731125

upstream raw materials:

ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate

sodium cyanide

ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate

3,4-dimethoxy-benzaldehyde

Downstream raw materials:

4-acetamido-3-(3,4-dimethoxyphenyl)butyronitrile

(+/-)-3-(3,4-dimethoxyphenyl)pyrrolidine

3-(3,4-dimethoxyphenyl)pyrrolidine-2,5-dione

2-(3,4-dimethoxyphenyl)-N-(n-propyl)succinimide