2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine

Base Information

Chemical Name:2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine
CAS No.:76686-93-6
Molecular Formula:C₇H₄ClN₃S
Molecular Weight:197.648
Hs Code.:
DSSTox Substance ID:DTXSID60504852
Wikidata:Q82359619

Synonyms:76686-93-6;2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine;2-chloro-5-pyridin-2-yl-1,3,4-thiadiazole;2-chloro-5-(pyridin-2-yl)-1,3,4-thiadiazole;Pyridine, 2-(5-chloro-1,3,4-thiadiazol-2-yl)-;SCHEMBL17135790;DTXSID60504852;BDA68693;AKOS012692923;CS-0232530;EN300-127480

Suppliers and Price of 2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine
100mg
$ 330.00

AK Scientific
2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine
2.5g
$ 1799.00

AK Scientific
2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine
250mg
$ 523.00

Total 4 raw suppliers

Chemical Property of 2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine

Chemical Property:

PSA：66.91000
LogP:2.25350
XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:196.9814460
Heavy Atom Count:12
Complexity:158

Purity/Quality:

99% ^*data from raw suppliers

2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=NC(=C1)C2=NN=C(S2)Cl

Technology Process of 2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine

There total 6 articles about 2-(5-Chloro-1,3,4-thiadiazol-2-yl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 25468-22-8
2-amino-5-(pyridin-2-yl)-1,3,4-thiadiazole

: 76686-93-6
2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine

Guidance literature:: 2-amino-5-(pyridin-2-yl)-1,3,4-thiadiazole; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

With copper(II) choride dihydrate; In water; at 0 ℃; for 2h;
DOI:10.1016/j.biopha.2020.110162

Reference yield:

: 3608-75-1
pyridine-2-carbaldehyde thiosemicarbazone

: 76686-93-6
2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: FeCl₃*6H₂O / ethanol / 2 h / Heating

2: conc. HCl, aq. NaNO₂, copper, glacial acetic acid / 4 h / 15 - 20 °C

With hydrogenchloride; iron(III) chloride; copper; acetic acid; sodium nitrite; In ethanol;
DOI:10.1021/jm00400a003

Reference yield:

: 1452-63-7
picolinic acid hydrazide

: 76686-93-6
2-(5-chloro-1,3,4-thiadiazol-2-yl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol / 4 h / 80 °C

1.2: 12 h / 20 °C

2.1: hydrogenchloride; sodium nitrite / water / 0 °C

2.2: 2 h / 0 °C

With hydrogenchloride; sodium nitrite; In ethanol; water; 2.1: |Sandmeyer Reaction / 2.2: |Sandmeyer Reaction;
DOI:10.1016/j.biopha.2020.110162