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3608-75-1

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3608-75-1 Usage

Purification Methods

Crystallise the derivative from EtOH, BuOH or water. Its hydrochloride crystallises from aqueous EtOH with m 237-239o (dec). [Beilstein 21 III/IV 3542 21/7 V 342.]

Check Digit Verification of cas no

The CAS Registry Mumber 3608-75-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,6,0 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3608-75:
(6*3)+(5*6)+(4*0)+(3*8)+(2*7)+(1*5)=91
91 % 10 = 1
So 3608-75-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H8N4S/c8-7(12)11-10-5-6-3-1-2-4-9-6/h1-5H,(H3,8,11,12)/b10-5+

3608-75-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (pyridin-2-ylmethylideneamino)thiourea

1.2 Other means of identification

Product number -
Other names Hydrazinecarbothioamide,2-(2-pyridinylmethylene)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3608-75-1 SDS

3608-75-1Relevant articles and documents

Transition metal complexes of 2-formylpyridinethiosemicarbazone (HFpyTSC) and X-ray crystal structures of [Pd(FpyTSC)(PPh3)]PF6and [Pd(FpyTSC)(SCN)]

Elsayed, Shadia A.,El-Hendawy, Ahmed M.,Mostafa, Sahar I.,Butler, Ian S.

, p. 2526 - 2532 (2010)

The syntheses of five new complexes of the 2- formylpyridinethiosemicarbazone ligand (HFpyTSC) with Pd(II) and Rh(III) ions are described, viz., [Pd(FpyTSC)(PPh3)]PF6, [Pd(FpyTSC)(SCN)], [Pd(FpyTSC)Br], [Pd(HFpyTSC)2]Brsu

Spectroscopic and biological approach of Ni(II) and Cu(II) complexes of 2-pyridinecarboxaldehyde thiosemicarbazone

Chandra, Sulekh,Raizada, Smriti,Tyagi, Monika,Sharma, Praveen Kumar

, p. 816 - 821 (2008)

Ni(II) and Cu(II) complexes having the general composition [M(L)2X2] [where L = 2-pyridinecarboxaldehyde thiosemicarbazone, M = Ni(II) and Cu(II), X = Cl-, NO3- and 1/2 SO42-] have been synthesized. All the metal complexes were characterized by elemental analysis, molar conductance, magnetic moment, mass, IR, EPR and electronic spectral studies. The magnetic moment measurements of the complexes indicate that all the complexes are of high-spin type. On the basis of spectral studies an octahedral geometry has been assigned for Ni(II) complexes whereas tetragonal geometry for Cu(II) except [Cu(L)2SO4] which posseses five coordinated geometry. The ligand and its metal complexes were screened against phytopathogenic fungi and bacteria in vitro.

A multi-responsive thiosemicarbazone-based probe for detection and discrimination of group 12 metal ions and its application in logic gates

Sarkar, Soma,Mondal, Tapashree,Roy, Swapnadip,Saha, Rajnarayan,Ghosh, Ashish Kumar,Panja, Sujit S.

, p. 15157 - 15169 (2018)

A new simple 3-in-1 multi-response thiosemicarbazone-based chemosensor has been synthesized and characterized. The probe not only exhibited high sensitivity towards the most familiar and abundant group 12 metal ions, viz., Zn2+, Cd2+ and Hg2+, in MeCN-H2O (1 : 1, v/v) medium but also can efficiently distinguish them through significant changes in their absorption and emission spectral behavior. The selectivity response was found to follow the order Hg2+, Cd2+, Zn2+ due to the different degrees of stability of their respective complexes, which was further established by TDDFT calculations and interference studies. The binding affinities of the probe towards these metal ions were investigated by absorption, fluorescence emission, fluorescence lifetime, mass spectral and 1H NMR spectral measurements. The effects of solvent polarity on the probe molecule were also examined. Due to the observation of different binding affinities and the ensuing significant changes in absorbance at different wavelengths by a combination of different inputs, L can be judiciously applied for the construction of some basic logic gates (AND, OR, NOT, IMPLICATION and INHIBIT).

Development of a multi-target anticancer Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complex

Li, Wenjuan,Liang, Hong,Pang, Min,Sun, Hongbin,Wang, Xiaojun,Wu, Junmiao,Yang, Feng,Yang, Tongfu

, p. 10909 - 10921 (2021/08/17)

In this study, we proposed to design effective multi-target anticancer agents based on the chelation of nontoxic metals with ligands that possess anticancer activity. In total, five Sn(ii) pyridine-2-carboxaldehyde thiosemicarbazone complexes are synthesi

Thiosemicarbazones exhibit inhibitory efficacy against New Delhi metallo-β-lactamase-1 (NDM-1)

Ge, Ying,Kang, Peng-Wei,Li, Jia-Qi,Gao, Han,Zhai, Le,Sun, Le-Yun,Chen, Cheng,Yang, Ke-Wu

, p. 574 - 579 (2021/07/17)

The superbug infection caused by metallo-β-lactamases (MβLs) carrying drug-resistant bacteria, specifically, New Delhi metallo-β-lactamase (NDM-1) has become an emerging threat. In an effort to develop novel inhibitors of NDM-1, thirteen thiosemicarbazones (1a-1m) were synthesized and assayed. The obtained molecules specifically inhibited NDM-1, with an IC50 in the range of 0.88–20.2 μM, and 1a and 1f were found to be the potent inhibitors (IC50 = 1.79 and 0.88 μM) using cefazolin as substrate. ITC and kinetic assays indicated that 1a irreversibly and non-competitively inhibited NDM-1 in vitro. Importantly, MIC assays revealed that these molecules by themselves can sterilize NDM-producing clinical isolates EC01 and EC08, exhibited 78-312-fold stronger activities than the cefazolin. MIC assays suggest that 1a (16 μg ml?1) has synergistic antimicrobial effect with ampicillin, cefazolin and meropenem on E. coli producing NDM-1, resulting in MICs of 4-32-, 4-32-, and 4-8-fold decrease, respectively. These studies indicate that the thiosemicarbazide is a valuable scaffold for the development of inhibitors of NDM-1 and NDM-1 carrying drug-resistant bacteria.

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