Z-GLU(OTBU)-ONP

Base Information

• Chemical Name: Z-GLU(OTBU)-ONP
• CAS No.: 7670-08-8
• Molecular Formula: C23H26N2O8
• Molecular Weight: 458.468
• Mol file: 7670-08-8.mol

Synonyms:Cbz-Glu(t-Bu)-ONp;Z-GLU(OBUT)-ONP;Z-GLUTAMIC ACID(OTBU)-ONP;Z-L-Glu(tBu)-ONp;N-[(Benzyloxy)carbonyl]-L-glutamic acid 5-(1,1-dimethylethyl)1-(4-nitrophenyl) ester;

Chemical Property of Z-GLU(OTBU)-ONP

Chemical Property:

• PSA: 136.75000
• LogP: 4.83120
• Storage Temp.: -15°C

Purity/Quality:

99% ^*data from raw suppliers

Z-L-Glu(tBu)-ONp ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Z-GLU(OTBU)-ONP

There total 1 articles about Z-GLU(OTBU)-ONP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) + 5-tert-butyl N-benzyloxycarbonyl-L-glutamate (3886-08-6) → (benzyloxycarbonyl)-γ-tert-butyl-L-glutamic acid p-nitrophenyl ester (7670-08-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In ethyl acetate;

Reference yield: 89.0%

(benzyloxycarbonyl)-γ-tert-butyl-L-glutamic acid p-nitrophenyl ester (7670-08-8) + H-Asp(Leu-Gly-OH)-OH (80451-95-2) → Z-Glu(O-But)-Asp(Leu-Gly-OH)-OH (80451-96-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

DOI:10.1246/bcsj.54.3088

Reference yield: 82.3%

L-arginine (74-79-3,25212-18-4) + (benzyloxycarbonyl)-γ-tert-butyl-L-glutamic acid p-nitrophenyl ester (7670-08-8) → Z-Glu(OtBu)-Arg-OH (69538-49-4)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃; for 24h;

upstream raw materials:

4-nitro-phenol

5-tert-butyl N-benzyloxycarbonyl-L-glutamate

Downstream raw materials:

Z-Glu-Thr-OMe

Z-Glu(O-But)-Asp(Leu-Gly-OH)-OH

(benzyloxycarbonyl)-γ-tert-butyl-L-glutamyl-L-alanyl-L-tyrosyl-glycine carbamoylmethyl ester

Z-Glu(OtBu)-Arg-OH

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