2-Methylindolizine

Base Information

• Chemical Name: 2-Methylindolizine
• CAS No.: 768-18-3
• Molecular Formula: C9H9N
• Molecular Weight: 131.177
• Mol file: 768-18-3.mol

Synonyms:2-Methyl-indolizin;2-methylindolizine;2-methyl-indolizine;

Chemical Property of 2-Methylindolizine

Chemical Property:

• Melting Point: 59.5 °C
• Boiling Point: 75-78 °C
• PSA: 4.41000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 2.24770

Purity/Quality:

95% ^*data from raw suppliers

2-methylindolizine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methylindolizine

There total 24 articles about 2-Methylindolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.2%

2-methyl-1-(2-oxo-propyl)-pyridinium; bromide (75487-74-0) → 2-methylindolizine (768-18-3)

Guidance literature:

With potassium hydrogencarbonate; In water; for 1h; Heating;

Reference yield: 76.0%

α-picoline (109-06-8) + chloroacetone (78-95-5) → 2-methylindolizine (768-18-3)

Guidance literature:

for 4h; Heating;

Reference yield: 67.0%

2-acetonylpyridine (6302-02-9) + diazomethyl-trimethyl-silane (18107-18-1) → 2-methylindolizine (768-18-3)

Guidance literature:

In methanol; diethyl ether; at 20 ℃; for 24h;

DOI:10.1016/j.tetlet.2008.01.067

upstream raw materials:

α-picoline

2-methyl-3-acetylindolizine

diethyl ether

ethylmagnesium bromide

Downstream raw materials:

2-methyl-3-indolizinecarbonyl chloride

2-methyl-indolizine-3-carbaldehyde

2-methyl-indolizine-1,3-dicarbaldehyde

(2-methylindolizin-3-yl)(phenyl)methanone

Refernces

• 1、 Zhu, Liusheng,Vimolratana, Marc,Brown, Sean P.,Medina, Julio C.. "A mild preparation of substituted indolizines and indole from simple aromatic precursors using (trimethylsilyl)diazomethane". . p. 1768 - 1770. Retrieved 2008/09/18.
• 2、 Xia, Zhiqiang,Przewloka, Teresa,Koya, Keizo,Ono, Mitsunori,Chen, Shoujun,Sun, Lijun. "Controlling chemoselectivity-application of DMF di-t-butyl acetal in the regioselective synthesis of 3-monosubstituted indolizines". . p. 8817 - 8820. Retrieved 2007/10/03.