1,4-Piperazinedicarboxylic acid, di-2-propynyl ester

Base Information

• Chemical Name: 1,4-Piperazinedicarboxylic acid, di-2-propynyl ester
• CAS No.: 768387-56-0
• Molecular Formula: C12H14N2O4
• Molecular Weight: 250.254
• Mol file: 768387-56-0.mol

Synonyms:

Chemical Property of 1,4-Piperazinedicarboxylic acid, di-2-propynyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1,4-Piperazinedicarboxylic acid, di-2-propynyl ester

There total 2 articles about 1,4-Piperazinedicarboxylic acid, di-2-propynyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperazine (110-85-0) + propargyl chloroformate (35718-08-2) → di(prop-2-ynyl) piperazine-1,4-dicarboxylate (768387-56-0)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1002/anie.200454078

Reference yield: 86.0%

propargyl chloroformate (35718-08-2) + N,N'-dibenzylpiperazine (1034-11-3) → di(prop-2-ynyl) piperazine-1,4-dicarboxylate (768387-56-0)

Guidance literature:

propargyl chloroformate; N,N'-dibenzylpiperazine; In chloroform; at -23 ℃;

In chloroform; at 20 ℃; for 0.2h; Further stages.;

DOI:10.1016/j.tetlet.2004.09.018

Reference yield: 96.0%

di(prop-2-ynyl) piperazine-1,4-dicarboxylate (768387-56-0) → piperazine (110-85-0)

Guidance literature:

With benzyltriethylammonium tetrathiomolybdate; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1016/j.tetlet.2004.09.018

upstream raw materials:

piperazine

propargyl chloroformate

N,N'-dibenzylpiperazine

Downstream raw materials:

piperazine